Melissa Rauch as Bernadette Rostenkowski-Wolowitz (recurring season 3, starring seasons 4–12): A young woman who initially is a co-worker at The Cheesecake Factory with Penny to pay her way through graduate school, where she is studying microbiology. Bernadette is introduced to Howard by Penny; at first, they do not get along, apparently having nothing in common. They date and later get engaged and married. Although generally a sweet and good-natured person, Bernadette has a short fuse and can be vindictive and lash out when provoked.
^ Kondolojy, Amanda (November 8, 2013). "Thursday Final Ratings: 'Elementary', 'Scandal', 'The Vampire Diaries', & 'The Big Bang Theory' Adjusted Up; 'The Voice', 'The Millers', 'Sean Saves the World', 'Parenthood', & 'The Michael J Fox Show' Adjusted Down". TV by the Numbers. Archived from the original on November 8, 2013. Retrieved November 8, 2013.
With Leonard, Howard, Raj, and Amy accomplishing so much on their respective projects, Sheldon is forced to admit he has nothing important upon which to work. He makes Amy leave the apartment for a few days so he can focus, but cannot come up with any ideas and calls his mother as a distraction. Leonard and Amy have fun recreating experiments from when they were growing up, boring Penny, so she eats with Sheldon as he mulls over his scientific studies. Penny helps him realize that his study of dark matter is his rebound science from string theory, which Sheldon admits he never truly disregarded, but explaining string theory to her inspires Sheldon, helping him discover a potential breakthrough in the field. Meanwhile Howard is too busy with his family to be in the band with Raj, so Raj brings in Bert. But, when Howard annoys Bernadette by writing an astronaut-themed musical while she is on bed-rest, she makes him rejoin the band. The three are poorly received at a Bar mitzvah after singing Bert's original song about the boulder from Indiana Jones .
I had never heard of Jim Parsons until I watched BBT but, his performance as Sheldon Cooper should be recognized as one of the greatest in TV history and the individual responsible for casting him should be considered a genius. Jim was born to play Sheldon. No other actor could’ve owned this character the way he did. I hope he continues to share his talent with audiences in other ways!
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In the episode "The Launch Acceleration", Amy tries to use her "neurobiology bag of tricks" to increase the attraction between herself and Sheldon. In the final fifth-season episode "The Countdown Reflection", Sheldon takes Amy's hand as Howard is launched into space. In the sixth season first episode "The Date Night Variable", after a dinner in which Sheldon fails to live up to this expectation, Amy gives Sheldon an ultimatum that their relationship is over unless he tells her something from his heart. Amy accepts Sheldon's romantic speech even after learning that it is a line from the first Spider-Man movie. In "The Cooper/Kripke Inversion" Sheldon states that he has been working on his discomfort about physical contact and admits that "it's a possibility" that he could one day have sex with Amy. Amy is revealed to have similar feelings in "The Love Spell Potential". Sheldon explains that he never thought about intimacy with anyone before Amy.
Star Trek in particular is frequently referenced and Sheldon identifies strongly with the character of Spock, so much so that when he is given a used napkin signed by Leonard Nimoy as a Christmas gift from Penny he is overwhelmed with excitement and gratitude ("I possess the DNA of Leonard Nimoy?!"). Star Trek: The Original Series cast member George Takei has made a cameo, and Leonard Nimoy made a cameo as the voice of Sheldon's vintage Mr. Spock action figure (both cameos were in dream sequences). Star Trek: The Next Generation cast members Brent Spiner and LeVar Burton have had cameos as themselves, while Wil Wheaton has a recurring role as a fictionalized version of himself. Leonard and Sheldon have had conversations in the Klingon language.
Amy and Howard begin collaborating on a neuroprosthetics project, upsetting Sheldon and Raj, who feel they are not spending as much time with them. When they seek solace with an annoyed Bernadette, she exploits the situation to trick Sheldon into doing Howard's chores. Penny successfully employs the approaches recommended in one of Bernadette's parenting books to deal with Sheldon, but Leonard believes she is coddling Sheldon too much. Sheldon and Raj resolve the issue of missing their significant others by spending time together.
Leonard's mother Beverly visits, and he is thrilled when she takes an interest in his work. However, when he learns that she is doing research on him for a new parenting book, he is furious. He prepares to tell her how she let him down over the years, but instead chooses to accept and forgive her, and forgive himself for holding onto that resentment for so long. Beverley is touched that he forgave her and they share a genuine hug. Meanwhile, Anu gets a job offer in London. Raj prepares to fly out and propose to her, ready to follow her if she accepts. Howard stops Raj at the airport, saying there is a better match out there for him, convincing Raj to return home. Stuart and Denise are bothered by her creepy roommate Mitch, while Bernadette and Howard are tired of Denise constantly staying overnight with Stuart at their house. Stuart says he is ready to move in with Denise, and they say they love each other while convincing Mitch to move out.
Campbell and Pemberton start a publicity tour for their Nobel campaign, including appearing on The Ellen DeGeneres Show. Caltech reaches out to previous winners, including George Smoot, Kip Thorne and Frances H. Arnold, only to find that Sheldon has offended most of them in the past. Leonard and Penny convince them to show up to the reception, only for Pemberton and Campbell to crash the party. Leonard holds Sheldon back, only for Amy to verbally snap at them. Meanwhile, with Halley scared of the dark, Stuart and Bernadette turn Howard's story from his time in outer space into the children's book: The Frightened Little Astronaut. Howard is embarrassed until Bernadette talks him into helping children and Stuart's art career by letting it be published.
Sheldon needs half a billion dollars to prove his latest concept of string theory, which the University cannot afford to fund. Crowdfunding and selling some of his most valuable comic books to Stuart give him a small start. When Raj mentions gambling in Las Vegas, Sheldon goes there but is caught calculating odds by security before he can make any bets. Meanwhile, Amy takes Penny and Bernadette shopping for her wedding dress. She loves an old-fashioned one that the other girls admit that they find ugly, though Penny assures Amy she can make her own decisions about her wedding. Sheldon, however, comes home and sees Amy in the dress and loves how she looks.