When Amy sees Sheldon obsessively tying and untying his bow tie the day before their wedding, Amy tells him it doesn't need to be even because sometimes a little asymmetry looks good. On the day of the wedding, Sheldon stops his mother from trying to straighten his bow tie, saying it's supposed to be a little asymmetrical. When Mary comments that sometimes it’s the imperfect stuff that makes things perfect, Sheldon has a flash of inspiration and rushes to see Amy. Sheldon and Amy’s wedding is delayed as they excitedly work on a new theory of “super asymmetry”.
When Leonard receives a braggy Christmas letter from his brother, he feels bad about how little he and Penny have achieved in the past year. Leonard wonders if he and Penny should be thinking about the next step after two years of marriage, like buying a house or having a baby. Penny tells him she wants to do all those things someday, but she has a bunch of stuff she would like to do first.