Sheldon and Amy decide on a wedding date of May 12th. They want to have their reception at the Athenaeum at Caltech. While scouting the location, they are shocked to see Leonard and Penny eating there, as Leonard had told Sheldon their application had been denied. In reality, Leonard just wanted a place to avoid Sheldon. Kripke has booked the venue for his birthday party on the same day as the wedding. Leonard cleans radioactive sludge for Kripke to get the date for Sheldon as an apology for lying. Kripke eventually agrees to change the day but when Amy hears he wants to sing at the wedding, she suggests they get married at the Griffith Observatory instead. Meanwhile, Bernadette and Howard are unsure if one of them should quit their job to stay home with the children. Howard volunteers, but when left alone with the children he passes out exhausted, leaving Raj in charge. When Bernadette meets Penny for lunch, she realizes that she loves being at the office again, but doesn't want to leave the children. She and Howard promise to figure it out later after they take a nap.
Sheldon and Amy recruit Leonard to research and write citations for their paper on super asymmetry. While working in the campus library, Leonard and Raj discover a Russian paper that asserts that super asymmetry has no merit. Reluctantly, Leonard shares the news with Sheldon and Amy, who fall into a depressive state and do not leave their apartment. Meanwhile, Bernadette asks Denise to teach her how to play Fortnite: Battle Royale so that she can beat Howard. Despite losing to Howard in a rematch after all of her training, Bernadette revels in beating a disinterested Penny.
Barry Kripke says that he can get proof that Pemberton plagiarized his thesis, which would destroy his chances at the Nobel Prize. Sheldon and Amy decide not to pursue this; they want to win on their own merits. Leonard decides to get the information from Kripke. Amy and Sheldon give it to Pemberton and Campbell, as they refuse to blackmail them. Campbell is furious that Pemberton's dishonesty could hurt his own career. It is revealed that Campbell is sleeping with Pemberton's ex-wife, causing the pair to brawl. Afterwards, Campbell exposes Pemberton, causing Pemberton to be fired. Amy and Sheldon reject a drunken Campbell's request to join their team. Bernadette tells Howard that another waitress at the Cheesecake Factory was attracted to him back in the day, so she said Howard had hepatitis to scare her off. Howard obsesses over who it was, until he tells Bernadette she is the only one that matters to him.
Sheldon's mother Mary refuses to attend his wedding unless he invites his older brother George, with whom he is no longer speaking. Sheldon and Leonard fly to Texas to talk to George, who now owns a chain of tire stores. He refuses to attend and later explains to Leonard and Sheldon that the family sacrificed a lot to fund Sheldon's education, and he was stuck caring for their mother and sister Missy after their father died while Sheldon was in college. Sheldon never thanked him for this. Leonard takes George back to the hotel room where Sheldon apologizes for what he did and the brothers reconcile. George agrees to attend the wedding. Meanwhile, Howard and Bernadette's children contract pinkeye, infecting everyone except Penny, much to Amy's fury. 

After Sheldon reminds the guys about the time they mined Bitcoin without him, the guys go on a quest to find their suddenly valuable missing cryptocurrency. They realize the currency is on a laptop which Leonard gave to Penny when they dating, which she then gave to her ex-boyfriend Zack. After Leonard and Penny go to Zack's apartment, he shows them a seven-year-old video that Penny recorded on the laptop soon after she broke up with Leonard. Leonard is touched by the video which shows a drunk Penny lamenting the break-up of her relationship with him.

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