Leonard gives an interview on public radio where he admits physics research might be at a dead end. The university is furious and, while trying to think of reasons to put in a retraction, he depresses Sheldon into thinking he might be right. Howard and Raj come over and end up just as depressed. Getting drunk with Penny, the men go to the grave of Richard Feynman and realize there is hope for physics as long as they believe in it. Leonard accidentally sends a drunken email to Human Resources. Meanwhile, Amy and Bernadette agree with each other to keep quiet about the success in their careers so as not to upset Sheldon and Howard. While bragging to each other, they end up arguing which of their fields is better.


Producers, writers and others, including recurring guest star Wil Wheaton, joined the festivities on set and — hardly a spoiler alert — more laughing, crying and hugging ensued. Lorre embraced a happy Parsons, then moved on to each cast member as if it were a reception line. Galecki shared long, emotional hugs with his colleagues. After trying to keep their emotions under control for so long, it was finally time to just let go.
While opening their wedding gifts, Sheldon and Amy cannot figure out the purpose of the glass shard Leonard and Penny gave them. They decide it must be a clue to a scavenger hunt to the real gift. They eventually end up in the coffee shop where they first met and find a locket in the lost and found that they think must be the real gift. The glass shard was actually a crystal chakra wand that Raj gave as a gift to Howard and Bernadette, who then re-gifted it to Leonard and Penny, who finally passed it on as a joke. Leonard and Penny find it less funny when they are given a coded thank-you note they have to use to unlock their WiFi. After making out with his employee Denise at Sheldon and Amy's wedding reception, Stuart finally asks Denise out on a date; while preparing for the date, he has a spray-tan accident, but she just finds it funny and still goes out with him. Raj is depressed everyone else has a relationship and asks his father to arrange a marriage.

Sheldon cannot find the perfect wedding date and begins talking in his sleep, adopting the persona of a laid-back person who goes with the flow. Amy and Penny believe that his subconscious mind is trying to tell him to be more relaxed; his attempt to be so while wearing flip-flops ends in disaster. He decides to leave all the wedding planning to Amy while he wears a Star Trek uniform underneath his tuxedo. Meanwhile, Raj and Stuart both become interested in Bernadette's new coworker Ruchi. While she likes them both as friends, she does not want a relationship with anyone.

Howard dresses as Sheldon for Halloween at work, hurting Sheldon's feelings. When Howard does not apologize, Amy and Sheldon dress as Bernadette and Howard at Penny and Leonard's party, angering Bernadette. Sheldon and Bernadette later bond over their painful childhood memories. Leonard is upset that Penny does not seem to remember that their first kiss was on Halloween. Penny later admits she does remember, but does not like to think of their first kiss as an unromantic drunken hookup. She likes to imagine their first kiss was one they shared on Leonard's birthday, which pleases him.


Science has also interfered with the characters' romantic lives. Leslie breaks up with Leonard when he sides with Sheldon in his support for string theory rather than loop quantum gravity.[70] When Leonard joins Sheldon, Raj, and Howard on a three-month Arctic research trip, it separates Leonard and Penny at a time when their relationship is budding. When Bernadette takes an interest in Leonard's work, it makes both Penny and Howard envious and results in Howard confronting Leonard, and Penny asking Sheldon to teach her physics.[71] Sheldon and Amy also briefly end their relationship after an argument over which of their fields is superior.[72]
"It's different for everybody. It was time for me and I felt that. It's both simple and complicated. I don't have a diary that I could bring out and say, 'Here are the reasons as far as quote-unquote future plans in a concrete way or (that I had) a problem with coming here.' None of those things were true," he says. "I felt it was the right moment for me. But, it only helps so much to go through the end of something like this feeling you've made the right choice. It's still exceedingly emotional." 
Turning to total viewers, “Manifest” was the biggest gainer overall, on average adding 6.1 million viewers per episode. ABC’s “The Good Doctor” was second with an average viewer lift of just under 6 million. “New Amsterdam” (5.2 million viewer lift) and “A Million Little Things” (3.5 million viewer lift) were also among the top gainers in this measure, as was ABC’s “Whiskey Cavalier” (3.2 million viewer lift).
I agree with Jeff. The finale was hardly “perfect”. I thought they took the safest route possible; and there were only a few good laughs. Some of it was predictable; winning the Nobel and fixing the elevator. The prize ceremony wasn’t even particularly interesting. Having each friend stand and be recognized at a Nobel ceremony seemed way of place…even for Sheldon. The writers were obviously struggling this last season for new material , and the finale was no exception. I still think Raj should have ended up with ‘someone’, as they felt the need to pair everyone else off during the series. (Even Stuart got a girl.). All in all, I found the finale wanting. I thought going in that I might burn it to DVD as an episode to keep to watch again. I’ll pass.
However, no legal action was required to end production of the other show: as soon as it became known that the show was unlicensed, the actors quit and the producers canceled it.[209] Dmitriy Tankovich (who plays Leonard's counterpart, "Seva") said in an interview, "I'm upset. At first, the actors were told all legal issues were resolved. We didn't know it wasn't the case, so when the creators of The Big Bang Theory started talking about the show, I was embarrassed. I can't understand why our people first do, and then think. I consider this to be the rock bottom of my career. And I don't want to take part in a stolen show".[210]
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