Simon Helberg as Howard Wolowitz:[45] An aerospace engineer who got his Masters at MIT. Howard is Jewish and lived with his mother, Debbie (Carol Ann Susi). Unlike Sheldon, Leonard, Raj, Bernadette and Amy, Howard does not hold a doctorate. He goes into space, training as an astronaut and serving as a payload specialist. Howard initially fancies himself as a womanizer, but he later starts dating Bernadette, and they get engaged and married. Howard also has a tendency to waste money on toys and argues with Bernadette because of his oddly low income as an engineer and her high income as a pharmaceutical biochemist.
Howard and Raj are still fighting, so Howard dis-invites Raj to Halley's birthday party. However, when Stuart pulls out as party planner at the last minute, Raj agrees to plan the party, which doesn't turn out too well due to Halley being asleep, Bernadette being on bed rest, and no people turning up. When Howard and Raj get into a shoving match in the party's bounce house, they end up letting out their frustrations, but also having fun and reconciling. Leonard is depressed upon receiving his successful brother's Christmas card and attempts to make a list of what he and Penny accomplished this year, not coming up with much. This prompts them to think about their plans for the future, so they decide to go on trips and achieve more out of life together before starting a family. Sheldon cooks Amy a Little House on the Prairie-themed birthday dinner, which gives them both food poisoning. They eventually recover enough to attend Halley's birthday party with the others, where they have fun in the bouncy castle and then have sex in Howard and Bernadette's house.

Sheldon's childhood friend from Texas, Tam, is visiting the university with his son. Sheldon does not want to see him and the others wonder why Sheldon has never mentioned Tam. Tam is unaware Sheldon is angry with him, thinking they just naturally drifted apart. Sheldon's brother George does not know the reason either. Sheldon eventually reveals Tam promised he would move to California with Sheldon, but then got a girlfriend and stayed with her, leaving Sheldon feeling abandoned. Tam and Sheldon make up and Sheldon has Leonard take Tam to the airport. Meanwhile, Penny and Bernadette want to get to know Anu, impressed by her connections in the hotel industry. They tell her embarrassing things about Raj and wonder if they can go out with her again after Raj confronts them.
The Big Bang Theory premiered in the United States on September 24, 2007 on CBS. The series debuted in Canada on CTV in September 2007.[152] On February 14, 2008, the series debuted in the United Kingdom on channels E4 and Channel 4.[153] In Australia the first seven seasons of the series began airing on the Seven Network and 7mate from October 2015 and also gained the rights to season 8 in 2016, though the Nine Network has rights to air seasons nine & ten.[154][155] On January 22, 2018, it was announced that Nine had acquired the rights to Season 1–8.[156]
In scenes set at Howard's home, he interacts with his rarely-seen mother (voiced by Carol Ann Susi until her death) by shouting from room to room in the house. She similarly interacts with other characters in this manner.[85] She reflects the Jewish mother stereotype in some ways, such as being overly controlling of Howard's adult life and sometimes trying to make him feel guilty about causing her trouble. She is dependent on Howard, as she requires him to help her with her wig and makeup in the morning. Howard, in turn, is attached to his mother to the point where she still cuts his meat for him, takes him to the dentist, does his laundry and "grounds" him when he returns home after briefly moving out.[86] Until Howard's marriage to Bernadette in the fifth-season finale, Howard's former living situation led Leonard's psychiatrist mother to speculate that he may suffer from some type of pathology,[87] and Sheldon to refer to their relationship as Oedipal.[88] In season 8, Howard's mother dies in her sleep while in Florida, which devastates Howard and Stuart, who briefly lived with Mrs. Wolowitz.
Wil Wheaton brings William Shatner on his Professor Proton show to meet Sheldon, who gets so excited that he vomits on Shatner. Going to Wil to apologize, he finds Wil hosts a Dungeons & Dragons group with his celebrity friends including Shatner. Finding out Stuart is in the group and never told them, the guys make Stuart panic and quit. Wil secretly invites Leonard who discovers that the group also includes Shatner, Kevin Smith, Joe Manganiello and Kareem Abdul-Jabbar. Leonard tells Penny, who tells Amy and Bernadette, all three women having a crush on Manganiello. Because of that indiscretion, Wil kicks out Leonard and admonishes the guys for using him for his connections, and says that one of the worst things about being a celebrity is not knowing whether someone will like him for himself. To apologize, the guys invite Wil to play D&D with them at Leonard’s apartment, but Wil, secretly in the middle of a game with Penny, Amy and Bernadette and the group, politely turns them down, before allowing the girls to send them a photo of the events as payback.
^ "Editor's Note: With final Monday ratings in, The Big Bang Theory has now reached a new series high in viewers (16.32m) and was the night's top program in adults 18-49 (5.9/15), up a tenth from this morning. -- "Two and a Half Men" Soars to Its Best Adult 18-49 Rating in Three Years". CBS. March 9, 2010. Archived from the original on January 8, 2014. Retrieved January 5, 2013.
In the season eight finale, Sheldon and Amy get into a fight about commitment on their fifth anniversary. Amy tells Sheldon that she needs to think about the future of their relationship, unaware that Sheldon was about to propose to her. Season nine sees Sheldon harassing Amy about making up her mind until she breaks up with him. Both struggle with singlehood and trying to be friends for the next few weeks until they reunite in episode ten and have sex for the first time on Amy's birthday.

Campbell and Pemberton start a publicity tour for their Nobel campaign, including appearing on The Ellen DeGeneres Show. Caltech reaches out to previous winners, including George Smoot, Kip Thorne and Frances H. Arnold, only to find that Sheldon has offended most of them in the past. Leonard and Penny convince them to show up to the reception, only for Pemberton and Campbell to crash the party. Leonard holds Sheldon back, only for Amy to verbally snap at them. Meanwhile, with Halley scared of the dark, Stuart and Bernadette turn Howard's story from his time in outer space into the children's book: The Frightened Little Astronaut. Howard is embarrassed until Bernadette talks him into helping children and Stuart's art career by letting it be published.

After Sheldon reminds the guys about the time they mined Bitcoin without him, the guys go on a quest to find their suddenly valuable missing cryptocurrency. They realize the currency is on a laptop which Leonard gave to Penny when they dating, which she then gave to her ex-boyfriend Zack. After Leonard and Penny go to Zack's apartment, he shows them a seven-year-old video that Penny recorded on the laptop soon after she broke up with Leonard. Leonard is touched by the video which shows a drunk Penny lamenting the break-up of her relationship with him.
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