Two physicists from Chicago, Dr. Campbell and Dr. Pemberton, accidentally prove Sheldon and Amy's super-asymmetry theory. This puts them on track for a Nobel Prize, but Leonard points out they tend to go to the experimental scientists who prove a concept instead of theorists like Sheldon who come up with it. Meeting with them, they tell Sheldon they are willing to share the Prize but only three names can be on the submission, and they want to cut Amy out. Amy does not want to prevent Sheldon's lifelong dream, but he goes to President Seibert who agrees to fight for Amy on their behalf. Meanwhile, Bernadette's drug has been approved and she wants to promote Penny to lead the marketing team. Penny resists, knowing Bernadette's attitude at work and doubting her own inexperience to take the responsibility, but Bernadette uses reverse-psychology to get Penny to take the job. Penny mirrors Bernadette's commanding style to get the other employees in line, impressing Bernadette.
The men are excited that Bill Gates is visiting Penny's pharmaceutical company, although she says that she cannot bring them along. Sheldon believes that it's an April Fools' Day prank. Leonard sees what hotel Gates is staying at on Penny's schedule, so he, Raj and Howard meet him in the lobby the day before. Once Sheldon sees proof, the men twice send him to the wrong hotel as real pranks. Penny says Leonard can meet Gates for real, so he fakes being sick to avoid him. When Penny puts Gates on a video call, he recognizes Leonard from the previous night. Meanwhile, Amy is tired of Bernadette only talking about her children, so Bernadette uses her expanded parental brain to learn random science facts.
Howard and Raj are still fighting, so Howard dis-invites Raj to Halley's birthday party. However, when Stuart pulls out as party planner at the last minute, Raj agrees to plan the party, which doesn't turn out too well due to Halley being asleep, Bernadette being on bed rest, and no people turning up. When Howard and Raj get into a shoving match in the party's bounce house, they end up letting out their frustrations, but also having fun and reconciling. Leonard is depressed upon receiving his successful brother's Christmas card and attempts to make a list of what he and Penny accomplished this year, not coming up with much. This prompts them to think about their plans for the future, so they decide to go on trips and achieve more out of life together before starting a family. Sheldon cooks Amy a Little House on the Prairie-themed birthday dinner, which gives them both food poisoning. They eventually recover enough to attend Halley's birthday party with the others, where they have fun in the bouncy castle and then have sex in Howard and Bernadette's house.
^ "Editor's Note: With final Monday ratings in, The Big Bang Theory has now reached a new series high in viewers (16.32m) and was the night's top program in adults 18-49 (5.9/15), up a tenth from this morning. -- "Two and a Half Men" Soars to Its Best Adult 18-49 Rating in Three Years". CBS. March 9, 2010. Archived from the original on January 8, 2014. Retrieved January 5, 2013.
The Canadian alternative rock band Barenaked Ladies wrote and recorded the show's theme song, which describes the history and formation of the universe and the Earth. Co-lead singer Ed Robertson was asked by Lorre and Prady to write a theme song for the show after the producers attended one of the band's concerts in Los Angeles. By coincidence, Robertson had recently read Simon Singh's book Big Bang, and at the concert improvised a freestyle rap about the origins of the universe. Lorre and Prady phoned him shortly thereafter and asked him to write the theme song. Having been asked to write songs for other films and shows, but ending up being rejected because producers favored songs by other artists, Robertson agreed to write the theme only after learning that Lorre and Prady had not asked anyone else.
The first and second pilots of The Big Bang Theory were directed by James Burrows, who did not continue with the show. The reworked second pilot led to a 13-episode order by CBS on May 14, 2007. Prior to its airing on CBS, the pilot episode was distributed on iTunes free of charge. The show premiered on September 24, 2007, and was picked up for a full 22-episode season on October 19, 2007. The show is filmed in front of a live audience, and is produced by Warner Bros. Television and Chuck Lorre Productions. Production was halted on November 6, 2007, due to the Writers Guild of America strike. Nearly three months later, on February 4, 2008, the series was temporarily replaced by a short-lived sitcom, Welcome to The Captain. The series returned on March 17, 2008, in an earlier time slot and ultimately only 17 episodes were produced for the first season.
Keith Carradine has appeared in three episode as Penny's father, Wyatt, first in Season 4. Katey Sagal, who played the on-screen mother of Kaley Cuoco's character in the 2002-2005 sitcom 8 Simple Rules, has appeared as Penny's mother in one episode of The Big Bang Theory. Jack McBrayer has appeared in one episode of The Big Bang Theory as Penny's brother, Randall.
After Sheldon reminds the guys about the time they mined Bitcoin without him, the guys go on a quest to find their suddenly valuable missing cryptocurrency. They realize the currency is on a laptop which Leonard gave to Penny when they dating, which she then gave to her ex-boyfriend Zack. After Leonard and Penny go to Zack's apartment, he shows them a seven-year-old video that Penny recorded on the laptop soon after she broke up with Leonard. Leonard is touched by the video which shows a drunk Penny lamenting the break-up of her relationship with him.
However, no legal action was required to end production of the other show: as soon as it became known that the show was unlicensed, the actors quit and the producers canceled it. Dmitriy Tankovich (who plays Leonard's counterpart, "Seva") said in an interview, "I'm upset. At first, the actors were told all legal issues were resolved. We didn't know it wasn't the case, so when the creators of The Big Bang Theory started talking about the show, I was embarrassed. I can't understand why our people first do, and then think. I consider this to be the rock bottom of my career. And I don't want to take part in a stolen show".