Turning to total viewers, “Manifest” was the biggest gainer overall, on average adding 6.1 million viewers per episode. ABC’s “The Good Doctor” was second with an average viewer lift of just under 6 million. “New Amsterdam” (5.2 million viewer lift) and “A Million Little Things” (3.5 million viewer lift) were also among the top gainers in this measure, as was ABC’s “Whiskey Cavalier” (3.2 million viewer lift).
Melissa Rauch as Bernadette Rostenkowski-Wolowitz (recurring season 3, starring seasons 4–12):[51] A young woman who initially is a co-worker at The Cheesecake Factory with Penny to pay her way through graduate school, where she is studying microbiology. Bernadette is introduced to Howard by Penny; at first, they do not get along, apparently having nothing in common. They date and later get engaged and married. Although generally a sweet and good-natured person, Bernadette has a short fuse and can be vindictive and lash out when provoked.

Getting called into Human Resources for Amy's outburst, Mrs. Davis tells her and Sheldon they are blowing their chances at the Nobel Prize. Amy would be the fourth woman to win in Physics, pressuring her to be a role model for women everywhere. To calm down, they try a sensory deprivation tank, which Sheldon loves, but Amy's mood only worsens. Sheldon does not know how to help and ends up holding her while singing "Soft Kitty". A newly confident Amy goes back to Human Resources to be allowed to campaign again and shares a drink with Mrs. Davis. Meanwhile, Howard buys a scooter to ride with Raj like in the old days. Bernadette finds out and makes him sell it since it's too dangerous. Bert buys it and ends up meeting a nurse after he dislocates his arm in a wreck.
When Mayim Bialik first learned she had to say goodbye to neurobiologist Amy Farrah Fowler, she opened up about the show ending in a blog post, asking, "And now I start to figure out what next. Where will life take me? Where will this career go? What do I want?" Up next she has a voice role in The Inspector Chronicles, a quasi-parody of Doctor Who making the leap from short to feature film. She'll reprise her role as the voice of the Inspector's time machine, known as B.O.O.T.H. Aside from that, she doesn't have any major projects lined up, aside from preparing to not see her close-knit cast the way she'd grown accustomed to. "We'll have to see what our lives look like," she told Us Weekly in early May about the chance they'll remain close. "I mean, we're all going to be on different schedules now; it's very different."

"It's different for everybody. It was time for me and I felt that. It's both simple and complicated. I don't have a diary that I could bring out and say, 'Here are the reasons as far as quote-unquote future plans in a concrete way or (that I had) a problem with coming here.' None of those things were true," he says. "I felt it was the right moment for me. But, it only helps so much to go through the end of something like this feeling you've made the right choice. It's still exceedingly emotional." 


Sheldon and Amy's paper is a huge success, but Sheldon is upset when he is not allowed to do interviews, while Amy gets all the attention. Denise asks Stuart to move in with her but he panics and flees. Raj sets up a doorbell camera app for Anu but sees her greet her ex-boyfriend. At a paintball match, all the feuding couples argue, with Raj saying he cannot trust Anu since he does not even know her, throwing the wedding into question. Stuart makes up with Denise by giving her a key to the Wolowitz house. Sheldon tries to do one interview with Amy but leaves when he is asked about the Russian scientists who had earlier disproved their theory.

As the theme of the show revolves around science, many distinguished and high-profile scientists have appeared as guest stars on the show. Famous astrophysicist and Nobel laureate George Smoot had a cameo appearance in the second season.[56] Theoretical physicist Brian Greene appeared in the fourth season, as well as astrophysicist, science populizer, and physics outreach specialist Neil deGrasse Tyson, who also appeared in the twelfth season.
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