Professor Proton, Sheldon's favorite childhood show, is being rebooted. After unsuccessfully auditioning for the part, he goes to Wil Wheaton for acting tips for his second audition. However, Sheldon is later dismayed when Wil is offered the role instead. Talking it over with Arthur in his dreams, he is still upset to see his idol replaced and considers Wil an enemy again. Meanwhile, Howard gets a vasectomy while Bernadette is on bed rest. Penny offers to take care of Halley for them, but they insult her by expecting her to be irresponsible. Halley ends up saying her first word by calling Penny "Mama."
President Siebert charges Leonard with distributing some extra university funds in the form of a grant. Everyone begins sucking up to Leonard. Penny is impressed by Leonard's decisiveness but unimpressed when he cannot decide between Raj, Kripke and Dr. Lee (Maribeth Monroe), an ornithologist who works with crows. Leonard, realizing that people will be angry with him no matter who he gives the funds to, eventually awards the money to himself; many crows swarm his car afterwards. Meanwhile, a stressed out Bernadette starts hiding in Halley's playhouse after work so she can have time to herself. She is eventually joined by Penny and Amy. Howard reveals to Raj that he actually knows that Bernadette has been hiding out, but is keeping quiet about it so she can have her privacy and so he can use it to his advantage.
Wil Wheaton brings William Shatner on his Professor Proton show to meet Sheldon, who gets so excited that he vomits on Shatner. Going to Wil to apologize, he finds Wil hosts a Dungeons & Dragons group with his celebrity friends including Shatner. Finding out Stuart is in the group and never told them, the guys make Stuart panic and quit. Wil secretly invites Leonard who discovers that the group also includes Shatner, Kevin Smith, Joe Manganiello and Kareem Abdul-Jabbar. Leonard tells Penny, who tells Amy and Bernadette, all three women having a crush on Manganiello. Because of that indiscretion, Wil kicks out Leonard and admonishes the guys for using him for his connections, and says that one of the worst things about being a celebrity is not knowing whether someone will like him for himself. To apologize, the guys invite Wil to play D&D with them at Leonard’s apartment, but Wil, secretly in the middle of a game with Penny, Amy and Bernadette and the group, politely turns them down, before allowing the girls to send them a photo of the events as payback.

The first and second seasons were only available on DVD at their time of release in 2008[197] and 2009.[198] Starting with the release of the third season in 2010[199] and continuing every year with every new season, a Blu-ray disc set has also been released in conjunction with the DVD. In 2012, Warner Bros. released the first two seasons on Blu-ray,[200] marking the first time that all episodes were available on the Blu-ray disc format.
Through the use of his vanity cards at the end of episodes, Lorre alleged that the program had been plagiarized by a show produced and aired in Belarus. Officially titled Теоретики (The Theorists), the show features "clones" of the main characters, a similar opening sequence, and what appears to be a very close Russian translation of the scripts.[207] Lorre expressed annoyance and described his inquiry with the Warner Bros. legal department about options. The television production company and station's close relationship with the Belarus government was cited as the reason that any attempt to claim copyright infringement would be in vain because the company copying the episodes is operated by the government.[208]

When Bernadette tells Howard that she is expecting again, he is once again floored with fear about raising another child, particularly when he learns it’s a boy. Howard, who isn't athletically inclined, worries he will not be able to relate to a son who might one day expect his dad to be the stereotypical father. Despite his best attempts to get out of it, Howard has a vasectomy to avoid any future surprises and is placed on bed rest, joining his pregnant wife at home.
It was really hard to pick the right pic for this post, so here is a shot of us in a hug after we filmed the last group scene we would ever film for the series... and TONIGHT is THE NIGHT... it’s the series finale at 8pm EST and then there’s the Young Sheldon (season!) finale, and then a special behind the scenes show hosted by @kaleycuoco and @sanctionedjohnnygalecki and then the entire cast is on @colbertlateshow I hope you get a chance to tune in and i hope you enjoy all of it. If you enjoy it even half as much as we’ve enjoyed (LOVED) creating this show for the past 12 years, then that’ll be a WHOLE WHOLE lot of enjoyment. All of us will miss seeing you in this format, but we will be around in all sorts of ways, I assure you... love love love ❤️❤️❤️
Sheldon and Amy recruit Leonard to research and write citations for their paper on super asymmetry. While working in the campus library, Leonard and Raj discover a Russian paper that asserts that super asymmetry has no merit. Reluctantly, Leonard shares the news with Sheldon and Amy, who fall into a depressive state and do not leave their apartment. Meanwhile, Bernadette asks Denise to teach her how to play Fortnite: Battle Royale so that she can beat Howard. Despite losing to Howard in a rematch after all of her training, Bernadette revels in beating a disinterested Penny.

According to Steve Holland who is the show-runner starting with this season, Wil Wheaton will return in this season since his absence from Season 10.[2] And this has confirmed to be true since it has been stated that he reappeared in "The Proton Regeneration" (S11E6), along with Professor Proton[3], their first appearances since "The Opening Night Excitation" (S9E11) and "The Celebration Experimentation", respectively and a span of 43 episodes and a span of 37 episodes, respectively. Wil also returned in the 15th episode. Wil will also return for Sheldon and Amy's Wedding.
Sheldon's mother Mary refuses to attend his wedding unless he invites his older brother George, with whom he is no longer speaking. Sheldon and Leonard fly to Texas to talk to George, who now owns a chain of tire stores. He refuses to attend and later explains to Leonard and Sheldon that the family sacrificed a lot to fund Sheldon's education, and he was stuck caring for their mother and sister Missy after their father died while Sheldon was in college. Sheldon never thanked him for this. Leonard takes George back to the hotel room where Sheldon apologizes for what he did and the brothers reconcile. George agrees to attend the wedding. Meanwhile, Howard and Bernadette's children contract pinkeye, infecting everyone except Penny, much to Amy's fury.
The Canadian alternative rock band Barenaked Ladies wrote and recorded the show's theme song, which describes the history and formation of the universe and the Earth. Co-lead singer Ed Robertson was asked by Lorre and Prady to write a theme song for the show after the producers attended one of the band's concerts in Los Angeles. By coincidence, Robertson had recently read Simon Singh's book Big Bang,[25][26] and at the concert improvised a freestyle rap about the origins of the universe.[citation needed] Lorre and Prady phoned him shortly thereafter and asked him to write the theme song. Having been asked to write songs for other films and shows, but ending up being rejected because producers favored songs by other artists, Robertson agreed to write the theme only after learning that Lorre and Prady had not asked anyone else.[citation needed]
After Sheldon reminds the guys about the time they mined Bitcoin without him, the guys go on a quest to find their suddenly valuable missing cryptocurrency. They realize the currency is on a laptop which Leonard gave to Penny when they dating, which she then gave to her ex-boyfriend Zack. After Leonard and Penny go to Zack's apartment, he shows them a seven-year-old video that Penny recorded on the laptop soon after she broke up with Leonard. Leonard is touched by the video which shows a drunk Penny lamenting the break-up of her relationship with him.
Sheldon and Amy recruit Leonard to research and write citations for their paper on super asymmetry. While working in the campus library, Leonard and Raj discover a Russian paper that asserts that super asymmetry has no merit. Reluctantly, Leonard shares the news with Sheldon and Amy, who fall into a depressive state and do not leave their apartment. Meanwhile, Bernadette asks Denise to teach her how to play Fortnite: Battle Royale so that she can beat Howard. Despite losing to Howard in a rematch after all of her training, Bernadette revels in beating a disinterested Penny.
When Leonard receives a braggy Christmas letter from his brother, he feels bad about how little he and Penny have achieved in the past year. Leonard wonders if he and Penny should be thinking about the next step after two years of marriage, like buying a house or having a baby. Penny tells him she wants to do all those things someday, but she has a bunch of stuff she would like to do first. 
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