In scenes set at Howard's home, he interacts with his rarely-seen mother (voiced by Carol Ann Susi until her death) by shouting from room to room in the house. She similarly interacts with other characters in this manner.[85] She reflects the Jewish mother stereotype in some ways, such as being overly controlling of Howard's adult life and sometimes trying to make him feel guilty about causing her trouble. She is dependent on Howard, as she requires him to help her with her wig and makeup in the morning. Howard, in turn, is attached to his mother to the point where she still cuts his meat for him, takes him to the dentist, does his laundry and "grounds" him when he returns home after briefly moving out.[86] Until Howard's marriage to Bernadette in the fifth-season finale, Howard's former living situation led Leonard's psychiatrist mother to speculate that he may suffer from some type of pathology,[87] and Sheldon to refer to their relationship as Oedipal.[88] In season 8, Howard's mother dies in her sleep while in Florida, which devastates Howard and Stuart, who briefly lived with Mrs. Wolowitz.

Barry Kripke says that he can get proof that Pemberton plagiarized his thesis, which would destroy his chances at the Nobel Prize. Sheldon and Amy decide not to pursue this; they want to win on their own merits. Leonard decides to get the information from Kripke. Amy and Sheldon give it to Pemberton and Campbell, as they refuse to blackmail them. Campbell is furious that Pemberton's dishonesty could hurt his own career. It is revealed that Campbell is sleeping with Pemberton's ex-wife, causing the pair to brawl. Afterwards, Campbell exposes Pemberton, causing Pemberton to be fired. Amy and Sheldon reject a drunken Campbell's request to join their team. Bernadette tells Howard that another waitress at the Cheesecake Factory was attracted to him back in the day, so she said Howard had hepatitis to scare her off. Howard obsesses over who it was, until he tells Bernadette she is the only one that matters to him.
Kunal Nayyar as Rajesh Koothrappali:[46] A particle astrophysicist originally from New Delhi, India. Raj is initially unable to talk to women unless he drinks alcohol. Raj also has very feminine tastes and often takes on a stereotypical female role in his friendship with Howard as well as in the group of four men. Raj later dates Lucy (Kate Micucci), who also suffers from social anxiety, but it eventually ends; he later speaks to Penny without alcohol and thus overcomes his selective mutism. He begins dating Emily and their relationship later becomes exclusive. Raj also has a Yorkshire Terrier named Cinnamon.
Jim Parsons as Sheldon Cooper:[43] Originally from Galveston, Texas, Sheldon was a child prodigy with an eidetic memory who began college at the age of eleven, and earned a PhD at age sixteen. He is a theoretical physicist researching quantum mechanics and string theory, and despite his IQ of 187, he finds many routine aspects of social situations difficult to grasp. He is determined to have his own way, continually boasts of his intelligence, and has an extremely ritualized way of living. Despite these quirks, he begins a relationship with Amy Farrah Fowler, and they eventually marry.
Professor Proton, Sheldon's favorite childhood show, is being rebooted. After unsuccessfully auditioning for the part, he goes to Wil Wheaton for acting tips for his second audition. However, Sheldon is later dismayed when Wil is offered the role instead. Talking it over with Arthur in his dreams, he is still upset to see his idol replaced and considers Wil an enemy again. Meanwhile, Howard gets a vasectomy while Bernadette is on bed rest. Penny offers to take care of Halley for them, but they insult her by expecting her to be irresponsible. Halley ends up saying her first word by calling Penny "Mama."
It was really hard to pick the right pic for this post, so here is a shot of us in a hug after we filmed the last group scene we would ever film for the series... and TONIGHT is THE NIGHT... it’s the series finale at 8pm EST and then there’s the Young Sheldon (season!) finale, and then a special behind the scenes show hosted by @kaleycuoco and @sanctionedjohnnygalecki and then the entire cast is on @colbertlateshow I hope you get a chance to tune in and i hope you enjoy all of it. If you enjoy it even half as much as we’ve enjoyed (LOVED) creating this show for the past 12 years, then that’ll be a WHOLE WHOLE lot of enjoyment. All of us will miss seeing you in this format, but we will be around in all sorts of ways, I assure you... love love love ❤️❤️❤️
^ Kondolojy, Amanda (November 8, 2013). "Thursday Final Ratings: 'Elementary', 'Scandal', 'The Vampire Diaries', & 'The Big Bang Theory' Adjusted Up; 'The Voice', 'The Millers', 'Sean Saves the World', 'Parenthood', & 'The Michael J Fox Show' Adjusted Down". TV by the Numbers. Archived from the original on November 8, 2013. Retrieved November 8, 2013.
Howard dresses as Sheldon for Halloween at work, hurting Sheldon's feelings. When Howard does not apologize, Amy and Sheldon dress as Bernadette and Howard at Penny and Leonard's party, angering Bernadette. Sheldon and Bernadette later bond over their painful childhood memories. Leonard is upset that Penny does not seem to remember that their first kiss was on Halloween. Penny later admits she does remember, but does not like to think of their first kiss as an unromantic drunken hookup. She likes to imagine their first kiss was one they shared on Leonard's birthday, which pleases him.
Kevin Sussman as Stuart Bloom (recurring seasons 2–5, 7, starring seasons 6, 8–12):[54] A mild-mannered, under-confident owner of a comic book store. A competent artist, Stuart is a graduate of the prestigious Rhode Island School of Design, and though he is socially awkward he possesses slightly better social skills. Stuart implies he is in financial trouble and that the comic book store now also is his home. He is later invited to join the guys' group while Howard is in space. Stuart gets a new job caring for Howard's mother later. After Mrs. Wolowitz's death, Stuart continues to live in her home, along with Howard and Bernadette, until he finds a place of his own.
"Big Bang" thrived with the addition of new characters, including scientists Amy (Bialik) and Bernadette (Rauch) and comic-book-store owner Stuart (Kevin Sussman), says Helberg, part of the original cast with Galecki, Parsons, Cuoco and Nayyar. (The show eventually spawned a hit prequel spinoff, "Young Sheldon," which heads into its third season in the fall, most likely in the "Big Bang" time slot.)
Two physicists from Chicago, Dr. Campbell and Dr. Pemberton, accidentally prove Sheldon and Amy's super-asymmetry theory. This puts them on track for a Nobel Prize, but Leonard points out they tend to go to the experimental scientists who prove a concept instead of theorists like Sheldon who come up with it. Meeting with them, they tell Sheldon they are willing to share the Prize but only three names can be on the submission, and they want to cut Amy out. Amy does not want to prevent Sheldon's lifelong dream, but he goes to President Seibert who agrees to fight for Amy on their behalf. Meanwhile, Bernadette's drug has been approved and she wants to promote Penny to lead the marketing team. Penny resists, knowing Bernadette's attitude at work and doubting her own inexperience to take the responsibility, but Bernadette uses reverse-psychology to get Penny to take the job. Penny mirrors Bernadette's commanding style to get the other employees in line, impressing Bernadette.
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Wednesday night is the group's designated "comic book night"[77] because that is the day of the week when new comic books are released. The comic book store is run by fellow geek and recurring character Stuart. On a number of occasions, the group members have dressed up as pop culture characters, including The Flash, Aquaman, Frodo Baggins, Superman, Batman, Spock, The Doctor, Green Lantern, and Thor.[78] As a consequence of losing a bet to Stuart and Wil Wheaton, the group members are forced to visit the comic book store dressed as Catwoman, Wonder Woman, Batgirl, and Supergirl.[79] DC Comics announced that, to promote its comics, the company will sponsor Sheldon wearing Green Lantern T-shirts.[80]
According to Steve Holland who is the show-runner starting with this season, Wil Wheaton will return in this season since his absence from Season 10.[2] And this has confirmed to be true since it has been stated that he reappeared in "The Proton Regeneration" (S11E6), along with Professor Proton[3], their first appearances since "The Opening Night Excitation" (S9E11) and "The Celebration Experimentation", respectively and a span of 43 episodes and a span of 37 episodes, respectively. Wil also returned in the 15th episode. Wil will also return for Sheldon and Amy's Wedding.

When Mayim Bialik first learned she had to say goodbye to neurobiologist Amy Farrah Fowler, she opened up about the show ending in a blog post, asking, "And now I start to figure out what next. Where will life take me? Where will this career go? What do I want?" Up next she has a voice role in The Inspector Chronicles, a quasi-parody of Doctor Who making the leap from short to feature film. She'll reprise her role as the voice of the Inspector's time machine, known as B.O.O.T.H. Aside from that, she doesn't have any major projects lined up, aside from preparing to not see her close-knit cast the way she'd grown accustomed to. "We'll have to see what our lives look like," she told Us Weekly in early May about the chance they'll remain close. "I mean, we're all going to be on different schedules now; it's very different."

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