The episode opens with a short montage of clips from the series' twelve seasons, then segues to Sheldon and Amy, who are up late waiting for a call from the Nobel Committee. Following a prank call from Kripke, they are told they've won the Nobel Prize in Physics for their super-asymmetry work. The attention from the media and the university bothers Sheldon. Amy is saddened by an unflattering picture of her in a news report, so Raj convinces her to get a makeover. She loves her new look but Sheldon demands she change it back. Leonard calls him out for being rude, but Sheldon flees when he sees Penny emerge from the newly repaired elevator. Sheldon and Penny go to the Cheesecake Factory and Penny tells Sheldon that change is the only constant thing in life. On a TV, they see Bernadette and Howard take credit as Sheldon and Amy's best friends. Raj and Leonard defend Amy, with Leonard accidentally breaking Sheldon's DNA molecule model in Apartment 4A. Penny convinces Sheldon to ride in the elevator.
Professor Proton, Sheldon's favorite childhood show, is being rebooted. After unsuccessfully auditioning for the part, he goes to Wil Wheaton for acting tips for his second audition. However, Sheldon is later dismayed when Wil is offered the role instead. Talking it over with Arthur in his dreams, he is still upset to see his idol replaced and considers Wil an enemy again. Meanwhile, Howard gets a vasectomy while Bernadette is on bed rest. Penny offers to take care of Halley for them, but they insult her by expecting her to be irresponsible. Halley ends up saying her first word by calling Penny "Mama." 

The show was filmed in front of a live audience and was produced by Warner Bros. Television and Chuck Lorre Productions. The Big Bang Theory received mixed reviews from critics throughout its first season, but reception was more favorable in the second and third seasons. Later seasons saw a return to a lukewarm reception, with the show being criticized for a decline in comedic quality. Despite the mixed reviews, seven seasons of the show have ranked within the top ten of the final television season ratings, ultimately reaching the no. 1 spot in its eleventh season. The show was nominated for the Emmy Award for Outstanding Comedy Series from 2011 to 2014 and won the Emmy Award for Outstanding Lead Actor in a Comedy Series four times for Jim Parsons. It has so far won seven Emmy Awards from 46 nominations. Parsons also won the Golden Globe for Best Actor in a Television Comedy Series in 2011. The series has so far won 56 awards from 216 nominations. It has also spawned a prequel series in 2017 based on Parsons' character, Sheldon Cooper, named Young Sheldon, which also airs on CBS.
Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend. Written by Huggo

Through the use of his vanity cards at the end of episodes, Lorre alleged that the program had been plagiarized by a show produced and aired in Belarus. Officially titled Теоретики (The Theorists), the show features "clones" of the main characters, a similar opening sequence, and what appears to be a very close Russian translation of the scripts.[207] Lorre expressed annoyance and described his inquiry with the Warner Bros. legal department about options. The television production company and station's close relationship with the Belarus government was cited as the reason that any attempt to claim copyright infringement would be in vain because the company copying the episodes is operated by the government.[208]


Amy and Howard begin collaborating on a neuroprosthetics project, upsetting Sheldon and Raj, who feel they are not spending as much time with them. When they seek solace with an annoyed Bernadette, she exploits the situation to trick Sheldon into doing Howard's chores. Penny successfully employs the approaches recommended in one of Bernadette's parenting books to deal with Sheldon, but Leonard believes she is coddling Sheldon too much. Sheldon and Raj resolve the issue of missing their significant others by spending time together.
Kaley Cuoco's life after The Big Bang Theory is going to be animated. Cuoco has signed on to voice and executive produce DC Universe's new Harley Quinn series. She'll play the titular character in the new streaming series targeted toward mature audiences. In 2017, she got the rights to The Flight Attendant, a miniseries based on the book of the same name, which she was poised to star in. The Flight Attendant follows Cassandra Bowden, a flight attendant, who wakes up, hungover, in her hotel room with a dead body next to her. She goes about her day and heads back to New York. is she the killer? That's what she wonders. "This is the first time I have a project that I'm kind of nurturing from the beginning, so it's been a really interesting experience," she told PopSugar in March. "It's got a lot of aspects. It's very sexy. It's a really well-written book, which is why I wanted to option it. I'm ready to bring the character to life."
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The Big Bang Theory signs off for good on Thursday, May 16, meaning that there's only one last bazinga left in the pipeline before we're forced to say farewell to Sheldon, Leonard, Penny, and the gang after 12 laugh-filled seasons. And while there's still a few questions left to be answered by the big one-hour series finale—Will the elevator ever be fixed? And will we ever learn Penny's maiden name?—there's a bigger one looming for when the credits roll and it's all over. 
I have watched this program since the beginning. It has very often been zany and unpredictable….tonight it was neither. So everything is “nicey nicey” on the last show, but far from comedy. There have been many memorable comedy series finales …Newhart, Seinfeld, etc……unfortunaely, thus was not one of those and I am sad that a potentially great TV moment was squandered
Sheldon needs half a billion dollars to prove his latest concept of string theory, which the University cannot afford to fund. Crowdfunding and selling some of his most valuable comic books to Stuart give him a small start. When Raj mentions gambling in Las Vegas, Sheldon goes there but is caught calculating odds by security before he can make any bets. Meanwhile, Amy takes Penny and Bernadette shopping for her wedding dress. She loves an old-fashioned one that the other girls admit that they find ugly, though Penny assures Amy she can make her own decisions about her wedding. Sheldon, however, comes home and sees Amy in the dress and loves how she looks.
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