Sheldon and Amy struggle to choose a best man and maid of honor from their friends. They secretly decide to test and score them, allowing everyone to have an equal shot at either role. Once the gang finds out, none of them apart from Bernadette and Stuart want to be in the wedding. Sheldon settles for Stuart as best man but, once Leonard tells Sheldon that, as the groom, the decision is his alone, he picks Leonard. Amy is set to call Bernadette but, once Penny realizes Amy is her best friend, she immediately pitches herself for the position and Amy enthusiastically chooses her. Amy later makes Penny tell Bernadette the bad news.
Sheldon and Amy decide on a wedding date of May 12th. They want to have their reception at the Athenaeum at Caltech. While scouting the location, they are shocked to see Leonard and Penny eating there, as Leonard had told Sheldon their application had been denied. In reality, Leonard just wanted a place to avoid Sheldon. Kripke has booked the venue for his birthday party on the same day as the wedding. Leonard cleans radioactive sludge for Kripke to get the date for Sheldon as an apology for lying. Kripke eventually agrees to change the day but when Amy hears he wants to sing at the wedding, she suggests they get married at the Griffith Observatory instead. Meanwhile, Bernadette and Howard are unsure if one of them should quit their job to stay home with the children. Howard volunteers, but when left alone with the children he passes out exhausted, leaving Raj in charge. When Bernadette meets Penny for lunch, she realizes that she loves being at the office again, but doesn't want to leave the children. She and Howard promise to figure it out later after they take a nap.
Sheldon is still despondent over the disproving of his and Amy's theory on asymmetry. Leonard brings out a VHS tape of a pep talk that Sheldon recorded as a boy, but it turns out that his father had recorded a long-ago football game over it. Sheldon, however, is buoyed by a halftime pep talk his father gave the team, realizing he and his father had more in common than he previously thought. This causes Amy to view asymmetry and symmetry in another manner and they decide their theory may not be dead after all. Bernadette finds an old tape of Howard preparing to audition for The Magic Castle. She insists he fulfill his dream and audition with her as a coach, drawing on her beauty pageant experience. Howard eventually decides to audition his own way, and promptly botches his chances by accidentally destroying a judge's Rolex.
Amy and Howard begin collaborating on a neuroprosthetics project, upsetting Sheldon and Raj, who feel they are not spending as much time with them. When they seek solace with an annoyed Bernadette, she exploits the situation to trick Sheldon into doing Howard's chores. Penny successfully employs the approaches recommended in one of Bernadette's parenting books to deal with Sheldon, but Leonard believes she is coddling Sheldon too much. Sheldon and Raj resolve the issue of missing their significant others by spending time together.

I read through the article and all the comments (which makes me miss TBBT even more and it hasn’t been off the air a week yet) and noticed that 3 of my favs aren’t mentioned. (1) episode where a bully (Todd Sornecki) steals Sheldon’s online trophies and Penny kicks him in the nuts for Sheldon; (2) the episode where they reveals each others secrets (Leonard slept with Priya; Raj used Sheldon’s tooth brush; Howard told Raj foreigner give gifts to Americans for certain holidays and Sheldon put moths in Leonards food “for science”; (3) the episode where Amy and Sheldon go to the aquarium “as friends”, when Sheldon tells Amy “I can handle a lot of things Amy but getting over you isn’t one of them, I think we should just be friends” it breaks my heart everytime; (4) the episode where Priya buys Leonard glass and he walks into the cafeteria and causes mass chaos, that’s a classic; (5) the episode where Priya ruins the roommate agreement between Sheldon and Leonard, when Leonard buys Sheldon Greek food it’s hilarious. Sheldon gets back at Leonard & Priya by threatening to send an email to Priya’s parents telling that “she’s in a relationship with the whiter than marsmellow fluff Leonard Hofstedter”. Ok just one more, when they all take a road trip to speak at the science convention and Bernadette runs into her former professor/lover played by Rick Foxx and Sheldon banished Penny to the “love car” and Bernie and Howard sing Sonny & Cher “I got you Babe” is funnier than hell. I still crack up when I see Raj look down at Howard’s junk to measure Howard’s junk against Rick Foxx’s, I can’t believe the sensors let that through.
Sheldon needs half a billion dollars to prove his latest concept of string theory, which the University cannot afford to fund. Crowdfunding and selling some of his most valuable comic books to Stuart give him a small start. When Raj mentions gambling in Las Vegas, Sheldon goes there but is caught calculating odds by security before he can make any bets. Meanwhile, Amy takes Penny and Bernadette shopping for her wedding dress. She loves an old-fashioned one that the other girls admit that they find ugly, though Penny assures Amy she can make her own decisions about her wedding. Sheldon, however, comes home and sees Amy in the dress and loves how she looks.
The episode opens with a short montage of clips from the series' twelve seasons, then segues to Sheldon and Amy, who are up late waiting for a call from the Nobel Committee. Following a prank call from Kripke, they are told they've won the Nobel Prize in Physics for their super-asymmetry work. The attention from the media and the university bothers Sheldon. Amy is saddened by an unflattering picture of her in a news report, so Raj convinces her to get a makeover. She loves her new look but Sheldon demands she change it back. Leonard calls him out for being rude, but Sheldon flees when he sees Penny emerge from the newly repaired elevator. Sheldon and Penny go to the Cheesecake Factory and Penny tells Sheldon that change is the only constant thing in life. On a TV, they see Bernadette and Howard take credit as Sheldon and Amy's best friends. Raj and Leonard defend Amy, with Leonard accidentally breaking Sheldon's DNA molecule model in Apartment 4A. Penny convinces Sheldon to ride in the elevator.

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