Sheldon's childhood friend from Texas, Tam, is visiting the university with his son. Sheldon does not want to see him and the others wonder why Sheldon has never mentioned Tam. Tam is unaware Sheldon is angry with him, thinking they just naturally drifted apart. Sheldon's brother George does not know the reason either. Sheldon eventually reveals Tam promised he would move to California with Sheldon, but then got a girlfriend and stayed with her, leaving Sheldon feeling abandoned. Tam and Sheldon make up and Sheldon has Leonard take Tam to the airport. Meanwhile, Penny and Bernadette want to get to know Anu, impressed by her connections in the hotel industry. They tell her embarrassing things about Raj and wonder if they can go out with her again after Raj confronts them.
Science has also interfered with the characters' romantic lives. Leslie breaks up with Leonard when he sides with Sheldon in his support for string theory rather than loop quantum gravity.[70] When Leonard joins Sheldon, Raj, and Howard on a three-month Arctic research trip, it separates Leonard and Penny at a time when their relationship is budding. When Bernadette takes an interest in Leonard's work, it makes both Penny and Howard envious and results in Howard confronting Leonard, and Penny asking Sheldon to teach her physics.[71] Sheldon and Amy also briefly end their relationship after an argument over which of their fields is superior.[72]
Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend. Written by Huggo
Cosmologist Stephen Hawking made a short guest appearance in the fifth-season episode;[57] in the eighth season, Hawking video conferences with Sheldon and Leonard, and makes another appearance in the 200th episode. In the fifth and sixth seasons, NASA astronaut Michael J. Massimino played himself multiple times in the role of Howard's fellow astronaut. Bill Nye appeared in the seventh and twelfth seasons.

The show made its United Kingdom debut on Channel 4 on February 14, 2008. The show was also shown as a 'first-look' on Channel 4's digital offshoot E4 prior to the main channel's airing. While the show's ratings were not deemed strong enough for the main channel, they were considered the opposite for E4. For each following season, all episodes were shown first-run on E4, with episodes only aired on the main channel in a repeat capacity, usually on a weekend morning. From the third season, the show aired in two parts, being split so that it could air new episodes for longer throughout the year. This was due to rising ratings. The first part began airing on December 17, 2009, at 9:00 p.m. while the second part, containing the remaining eleven episodes, began airing in the same time period from May 6, 2010. The first half of the fourth season began airing on November 4, 2010, at 9:00 p.m., drawing 877,000 viewers, with a further 256,000 watching on the E4+1 hour service. This gave the show an overall total of 1.13 million viewers, making it E4's most-watched programme for that week. The increased ratings continued over subsequent weeks.[144]
Howard and Bernadette learn their second child will be a boy, leading Howard to doubt whether he can be a good father to a son. He and Sheldon go out in the desert to test launch a model rocket, but it explodes, causing him further doubt. On the way home, Howard does a good job coaching Sheldon to drive them home, for which Sheldon tells him he will be a good teacher to his son. Leonard's mother Beverly begins talking to Penny as a friend and confidant, troubling Leonard, especially when he learns that Beverly told Penny that she was proud of her, a level of praise she never bestowed upon Leonard himself. When Leonard confronts Beverly, he is touched when she says that of all of her children's spouses, Penny is the one by whom she is most impressed and that, for this, she is indeed proud of him. Meanwhile, Raj helps Bernadette turn baby girl clothes into boy ones.
With Melissa Rauch saying goodbye to Bernadette Rostenkowski-Wolowitz after joining the show in season three and becoming a series regular in season four, she's already begun to carve out new gigs. Not only did her indie film Ode to Joy make its film festival debut this part April, but she has another film, Steven Soderbergh's The Laundromat co-starring none other than Meryl Streep, in post-production, due for a 2019 release. While wrapping up filming on TBBT, she landed her next TV gig, playing Shira, wife of Paul Scheer's Keith on Showtime's recent Wall Street comedy Black Sunday. With the show recently renewed for a second season to debut on the cable net in 2020, it's looking likely she'll be back with greater availability.
Sheldon needs half a billion dollars to prove his latest concept of string theory, which the University cannot afford to fund. Crowdfunding and selling some of his most valuable comic books to Stuart give him a small start. When Raj mentions gambling in Las Vegas, Sheldon goes there but is caught calculating odds by security before he can make any bets. Meanwhile, Amy takes Penny and Bernadette shopping for her wedding dress. She loves an old-fashioned one that the other girls admit that they find ugly, though Penny assures Amy she can make her own decisions about her wedding. Sheldon, however, comes home and sees Amy in the dress and loves how she looks.
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