Leonard and Sheldon are brilliant physicists—geniuses in the laboratory but socially challenged everywhere else. Enter beautiful, street-smart neighbor Penny, who aims to teach them a thing or two about life. Despite their on-again, off-again relationship in the past, Leonard and Penny have finally gotten married. Even Sheldon has found a female companion, entering into a "relationship agreement" with neurobiologist Amy Farrah Fowler, and he recently took their relationship to the next level by marrying her after a long courtship. In their free time, Leonard and Sheldon enjoy fantasy role-playing games with their ever-expanding universe of friends, including fellow scientists Koothrappali, Wolowitz, and Wolowitz’s adorable microbiologist wife, Bernadette, who is adjusting to life with their two children.
"The Locomotive Manipulation" is the first episode in which Sheldon initiates a kiss with Amy. Although initially done in a fit of sarcasm, he discovers that he enjoys the feeling. Consequently, Sheldon slowly starts to open up over the rest of the season, and starts a more intimate relationship with Amy. However, in the season finale, Sheldon leaves temporarily to cope with several changes and Amy becomes distraught. However, in "The Prom Equivalency", he hides in his room to avoid going to a mock prom reenactment with her. In the resulting stand-off, Amy is about to confess that she loves Sheldon, but he surprises her by saying that he loves her too. This prompts Amy to have a panic attack.
Sheldon cannot find the perfect wedding date and begins talking in his sleep, adopting the persona of a laid-back person who goes with the flow. Amy and Penny believe that his subconscious mind is trying to tell him to be more relaxed; his attempt to be so while wearing flip-flops ends in disaster. He decides to leave all the wedding planning to Amy while he wears a Star Trek uniform underneath his tuxedo. Meanwhile, Raj and Stuart both become interested in Bernadette's new coworker Ruchi. While she likes them both as friends, she does not want a relationship with anyone.
Johnny Galecki as Leonard Hofstadter:[42] An experimental physicist with an IQ of 173, who received his PhD when he was 24 years old. Leonard is a nerd who loves video games, comic books, and Dungeons & Dragons. Leonard is the straight man of the series, in which he shares an apartment in Pasadena, CA, with Sheldon. Leonard is smitten with his new neighbor Penny when they first meet, and they eventually marry.
Sheldon's mother Mary refuses to attend his wedding unless he invites his older brother George, with whom he is no longer speaking. Sheldon and Leonard fly to Texas to talk to George, who now owns a chain of tire stores. He refuses to attend and later explains to Leonard and Sheldon that the family sacrificed a lot to fund Sheldon's education, and he was stuck caring for their mother and sister Missy after their father died while Sheldon was in college. Sheldon never thanked him for this. Leonard takes George back to the hotel room where Sheldon apologizes for what he did and the brothers reconcile. George agrees to attend the wedding. Meanwhile, Howard and Bernadette's children contract pinkeye, infecting everyone except Penny, much to Amy's fury.

Anu wants to have sex with Raj, but he gets so nervous in the leadup, that his selective mutism returns. Confessing to her, she is very understanding, revealing an unusual secret of her own. The next morning, he is able to have sex with her in the shower. Sheldon attempts to bond with his father-in-law, but Larry is more impressed with Howard's magic tricks, causing a jealous Sheldon to spend time with Mrs. Fowler. They bond after finding out Amy has been using Sheldon as an excuse to avoid her mother, though he does gently advise her to forgive her daughter like he would his wife. A remorseful Amy invites the Fowlers over for thanksgiving, where Sheldon and Mrs. Fowler continue to bond over Larry's ineptitude with magic.


"It's different for everybody. It was time for me and I felt that. It's both simple and complicated. I don't have a diary that I could bring out and say, 'Here are the reasons as far as quote-unquote future plans in a concrete way or (that I had) a problem with coming here.' None of those things were true," he says. "I felt it was the right moment for me. But, it only helps so much to go through the end of something like this feeling you've made the right choice. It's still exceedingly emotional." 
"The Locomotive Manipulation" is the first episode in which Sheldon initiates a kiss with Amy. Although initially done in a fit of sarcasm, he discovers that he enjoys the feeling. Consequently, Sheldon slowly starts to open up over the rest of the season, and starts a more intimate relationship with Amy. However, in the season finale, Sheldon leaves temporarily to cope with several changes and Amy becomes distraught. However, in "The Prom Equivalency", he hides in his room to avoid going to a mock prom reenactment with her. In the resulting stand-off, Amy is about to confess that she loves Sheldon, but he surprises her by saying that he loves her too. This prompts Amy to have a panic attack.
'The Big Bang Theory' executive producers Chuck Lorre, left, and Steve Hollland and stars Kevin Sussman, Mayim Bialik, Jim Parsons, Kaley Cuoco and Kunal Nayyar stand to the left of 'The Big Bang Theory' stage plaque, with executive producer Bill Prady, star Melissa Rauch, executive producer Steven Molaro and star Johnny Galecki, director Mark Cendrowski and star Simon Helberg on the right. (Photo: Warner Bros.)
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After Sheldon reminds the guys about the time they mined Bitcoin without him, the guys go on a quest to find their suddenly valuable missing cryptocurrency. They realize the currency is on a laptop which Leonard gave to Penny when they dating, which she then gave to her ex-boyfriend Zack. After Leonard and Penny go to Zack's apartment, he shows them a seven-year-old video that Penny recorded on the laptop soon after she broke up with Leonard. Leonard is touched by the video which shows a drunk Penny lamenting the break-up of her relationship with him.
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