Sheldon's childhood friend from Texas, Tam, is visiting the university with his son. Sheldon does not want to see him and the others wonder why Sheldon has never mentioned Tam. Tam is unaware Sheldon is angry with him, thinking they just naturally drifted apart. Sheldon's brother George does not know the reason either. Sheldon eventually reveals Tam promised he would move to California with Sheldon, but then got a girlfriend and stayed with her, leaving Sheldon feeling abandoned. Tam and Sheldon make up and Sheldon has Leonard take Tam to the airport. Meanwhile, Penny and Bernadette want to get to know Anu, impressed by her connections in the hotel industry. They tell her embarrassing things about Raj and wonder if they can go out with her again after Raj confronts them.
Anu wants to have sex with Raj, but he gets so nervous in the leadup, that his selective mutism returns. Confessing to her, she is very understanding, revealing an unusual secret of her own. The next morning, he is able to have sex with her in the shower. Sheldon attempts to bond with his father-in-law, but Larry is more impressed with Howard's magic tricks, causing a jealous Sheldon to spend time with Mrs. Fowler. They bond after finding out Amy has been using Sheldon as an excuse to avoid her mother, though he does gently advise her to forgive her daughter like he would his wife. A remorseful Amy invites the Fowlers over for thanksgiving, where Sheldon and Mrs. Fowler continue to bond over Larry's ineptitude with magic.
The episode opens with a short montage of clips from the series' twelve seasons, then segues to Sheldon and Amy, who are up late waiting for a call from the Nobel Committee. Following a prank call from Kripke, they are told they've won the Nobel Prize in Physics for their super-asymmetry work. The attention from the media and the university bothers Sheldon. Amy is saddened by an unflattering picture of her in a news report, so Raj convinces her to get a makeover. She loves her new look but Sheldon demands she change it back. Leonard calls him out for being rude, but Sheldon flees when he sees Penny emerge from the newly repaired elevator. Sheldon and Penny go to the Cheesecake Factory and Penny tells Sheldon that change is the only constant thing in life. On a TV, they see Bernadette and Howard take credit as Sheldon and Amy's best friends. Raj and Leonard defend Amy, with Leonard accidentally breaking Sheldon's DNA molecule model in Apartment 4A. Penny convinces Sheldon to ride in the elevator.

The men are excited that Bill Gates is visiting Penny's pharmaceutical company, although she says that she cannot bring them along. Sheldon believes that it's an April Fools' Day prank. Leonard sees what hotel Gates is staying at on Penny's schedule, so he, Raj and Howard meet him in the lobby the day before. Once Sheldon sees proof, the men twice send him to the wrong hotel as real pranks. Penny says Leonard can meet Gates for real, so he fakes being sick to avoid him. When Penny puts Gates on a video call, he recognizes Leonard from the previous night. Meanwhile, Amy is tired of Bernadette only talking about her children, so Bernadette uses her expanded parental brain to learn random science facts.
Professor Proton, Sheldon's favorite childhood show, is being rebooted. After unsuccessfully auditioning for the part, he goes to Wil Wheaton for acting tips for his second audition. However, Sheldon is later dismayed when Wil is offered the role instead. Talking it over with Arthur in his dreams, he is still upset to see his idol replaced and considers Wil an enemy again. Meanwhile, Howard gets a vasectomy while Bernadette is on bed rest. Penny offers to take care of Halley for them, but they insult her by expecting her to be irresponsible. Halley ends up saying her first word by calling Penny "Mama."
Sheldon has been writing to the reclusive scientist Dr. Wolcott (Peter MacNicol) who invites Sheldon to visit him in his completely isolated mountain cabin. The women quickly ask Leonard, Raj and Howard to tag along with him, making this his bachelor party, despite Sheldon's assertions that it shouldn't be called such. Wolcott has a brilliant mind but his behavior is very strange to the guys. He tells Sheldon he cut off all contact with others to focus on science. Though Sheldon enjoys the science, he decides that he doesn't want to live like Wolcott because of his friends and Amy. The guys leave to avoid Wolcott, whose theories about time make him doubt whether the guys were ever there. Meanwhile, Penny and Bernadette throw Amy a quilting bee for her bachelorette party, which she quickly finds boring. When Amy tells them she wants a night full of bad decisions as she earlier implied, they go to a bar where Amy drinks a few shots and passes out in twelve minutes. When she wakes up back at the apartment hungover and disappointed, the women lie and reassure her she had a wild time, involving her drunkenly riverdancing.
I’m sure someone will start a petition to redo the finale because Sheldon’s speech was “out of character” for him, like Game of Thrones, lol. Seriously, they really did wrap up the show perfectly. Even though they had the Nobel Prize win and pregnancy and the Buffy cameo, they really didn’t rely on a bunch of craziness or twists or a ton of cameos or the things many series finales attempt to do. Instead, they just leaned into the strengths of the show and let the actors do their thing. That Sheldon speech was a great way to end things.
The CBS sitcom said goodbye on Thursday night after a storied 12-season run — and now that it’s really over, we’re feeling super nostalgic. Having already revisited the pilot episode, highlighted classic “Shamy” moments and ranked our favorite recurring characters, we’re closing out our retrospective coverage with a list of the 10 episodes that we feel are a cut above the rest.

Sheldon is still despondent over the disproving of his and Amy's theory on asymmetry. Leonard brings out a VHS tape of a pep talk that Sheldon recorded as a boy, but it turns out that his father had recorded a long-ago football game over it. Sheldon, however, is buoyed by a halftime pep talk his father gave the team, realizing he and his father had more in common than he previously thought. This causes Amy to view asymmetry and symmetry in another manner and they decide their theory may not be dead after all. Bernadette finds an old tape of Howard preparing to audition for The Magic Castle. She insists he fulfill his dream and audition with her as a coach, drawing on her beauty pageant experience. Howard eventually decides to audition his own way, and promptly botches his chances by accidentally destroying a judge's Rolex.
Sheldon needs half a billion dollars to prove his latest concept of string theory, which the University cannot afford to fund. Crowdfunding and selling some of his most valuable comic books to Stuart give him a small start. When Raj mentions gambling in Las Vegas, Sheldon goes there but is caught calculating odds by security before he can make any bets. Meanwhile, Amy takes Penny and Bernadette shopping for her wedding dress. She loves an old-fashioned one that the other girls admit that they find ugly, though Penny assures Amy she can make her own decisions about her wedding. Sheldon, however, comes home and sees Amy in the dress and loves how she looks.
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