The episode opens with a short montage of clips from the series' twelve seasons, then segues to Sheldon and Amy, who are up late waiting for a call from the Nobel Committee. Following a prank call from Kripke, they are told they've won the Nobel Prize in Physics for their super-asymmetry work. The attention from the media and the university bothers Sheldon. Amy is saddened by an unflattering picture of her in a news report, so Raj convinces her to get a makeover. She loves her new look but Sheldon demands she change it back. Leonard calls him out for being rude, but Sheldon flees when he sees Penny emerge from the newly repaired elevator. Sheldon and Penny go to the Cheesecake Factory and Penny tells Sheldon that change is the only constant thing in life. On a TV, they see Bernadette and Howard take credit as Sheldon and Amy's best friends. Raj and Leonard defend Amy, with Leonard accidentally breaking Sheldon's DNA molecule model in Apartment 4A. Penny convinces Sheldon to ride in the elevator.

The scene is all business – at least as much as you can expect from a bunch of cut-ups making a sitcom – and no one seems distracted by two significant events: The episode will mark the show’s 276th, moving it past “Cheers” to set a record for a sitcom filmed in front of a studio audience, and only three more remain to be shot for "Big Bang," co-created by Chuck Lorre and Bill Prady. 
Live+7 data is currently available only through May 5, but the top dogs will likely see little change once the final numbers are in for the traditional September-May season. The top gainer in adults 18-49 was NBC’s “This Is Us” with an average lift of 1.8 ratings points. The number two spot was a tie between CBS’ “Big Bang Theory” and NBC’s “Manifest,” with both of those shows adding 1.5 ratings points on average. These numbers do not include “Big Bang Theory’s” series finale, however, which pulled in a 3.1 rating and 18 million viewers in Live+Same Day alone on May 16.

However, no legal action was required to end production of the other show: as soon as it became known that the show was unlicensed, the actors quit and the producers canceled it.[209] Dmitriy Tankovich (who plays Leonard's counterpart, "Seva") said in an interview, "I'm upset. At first, the actors were told all legal issues were resolved. We didn't know it wasn't the case, so when the creators of The Big Bang Theory started talking about the show, I was embarrassed. I can't understand why our people first do, and then think. I consider this to be the rock bottom of my career. And I don't want to take part in a stolen show".[210]
Sara Gilbert as Leslie Winkle (recurring season 1, starring season 2, guest seasons 3, 9):[47][48][49] A physicist who works in the same lab as Leonard. In appearance, she is essentially Leonard's female counterpart and has conflicting scientific theories with Sheldon. Leslie has casual sex with Leonard and later Howard. Gilbert was promoted to a main cast member during the second season but resumed guest star status because producers could not come up with enough material for the character.[47] Gilbert returned to The Big Bang Theory for its 200th episode.[50]
Penny runs into her ex-boyfriend Zack, who has gotten rich from selling his company and married a similarly dim-witted woman named Marissa. Meeting with Leonard and Penny, they say Zack is infertile and ask to pay Leonard as a sperm donor so they can have a baby. Leonard is flattered, but Penny finds it creepy. Leonard says that since Penny decided she did not want to have children, he should be allowed to help another couple with this issue. Sheldon advises him to think about the emotional toll this could have on him. Leonard says he will not do it if Penny objects; Penny says she will support whatever decision Leonard makes. Meanwhile, Raj tries to get Anu back but she points out he just wanted to be married like his friends. Raj points out that Anu is similarly looking for a quick marriage. He admits to Anu that he really likes her and they decide to start their relationship as just dating.

However, no legal action was required to end production of the other show: as soon as it became known that the show was unlicensed, the actors quit and the producers canceled it.[209] Dmitriy Tankovich (who plays Leonard's counterpart, "Seva") said in an interview, "I'm upset. At first, the actors were told all legal issues were resolved. We didn't know it wasn't the case, so when the creators of The Big Bang Theory started talking about the show, I was embarrassed. I can't understand why our people first do, and then think. I consider this to be the rock bottom of my career. And I don't want to take part in a stolen show".[210]
Sheldon is annoyed that Amy does not have time to work on the super-asymmetry project with him so he talks President Siebert into getting her removed from her own project at the university. Amy is angry at both of them as she wants to still have her own identity outside the marriage. When confronted by Amy, Siebert apologizes to her but states that it will be difficult for the university to give her her project back. After talking with Arthur Jeffries in a dream, Sheldon apologizes to Amy and both of them talk about their fears in their marriage. Meanwhile, Raj does not want to have Howard join him in his show at the planetarium, thinking he'd just use his astronaut status to make it about himself. Raj eventually lets him join in and Raj and Howard spend the whole time complimenting each other, surprising Bernadette, Leonard and Penny.

Sheldon needs half a billion dollars to prove his latest concept of string theory, which the University cannot afford to fund. Crowdfunding and selling some of his most valuable comic books to Stuart give him a small start. When Raj mentions gambling in Las Vegas, Sheldon goes there but is caught calculating odds by security before he can make any bets. Meanwhile, Amy takes Penny and Bernadette shopping for her wedding dress. She loves an old-fashioned one that the other girls admit that they find ugly, though Penny assures Amy she can make her own decisions about her wedding. Sheldon, however, comes home and sees Amy in the dress and loves how she looks.

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