Professor Proton, Sheldon's favorite childhood show, is being rebooted. After unsuccessfully auditioning for the part, he goes to Wil Wheaton for acting tips for his second audition. However, Sheldon is later dismayed when Wil is offered the role instead. Talking it over with Arthur in his dreams, he is still upset to see his idol replaced and considers Wil an enemy again. Meanwhile, Howard gets a vasectomy while Bernadette is on bed rest. Penny offers to take care of Halley for them, but they insult her by expecting her to be irresponsible. Halley ends up saying her first word by calling Penny "Mama."
Penny and Bernadette attend a pharmaceuticals conference, where Bernadette's business rival Danny tries to recruit Penny. Bernadette is offended that Penny is considering the offer. At the meeting with Danny, Bernadette steps in to say Penny is the best saleswoman she knows and Penny agrees to keep working for Bernadette. Meanwhile, the rest of the gang does simple behavioral experiments on the Wolowitz children using a book Sheldon found. Leonard is shocked that his childhood was filled with these experiments; although his mother remembers that time with him fondly, she admits the experiment with him is not over. Raj figures Amy planted the book to get Sheldon to like babies, though Sheldon later states he would be open to having kids.
“I have a very long and somewhat self-centered speech here, but I’d like to set it aside. Because this honor doesn’t just belong to me; I wouldn’t be up here if it weren’t for some very important people in my life,” he says, and thanks his family and his “other family.” “I was under a misapprehension that my accomplishments were mine alone. Nothing could be further from the truth. I have been encouraged, sustained, inspired, and tolerated, not only by my wife, but by the greatest group of friends anyone ever had.”
The men are excited that Bill Gates is visiting Penny's pharmaceutical company, although she says that she cannot bring them along. Sheldon believes that it's an April Fools' Day prank. Leonard sees what hotel Gates is staying at on Penny's schedule, so he, Raj and Howard meet him in the lobby the day before. Once Sheldon sees proof, the men twice send him to the wrong hotel as real pranks. Penny says Leonard can meet Gates for real, so he fakes being sick to avoid him. When Penny puts Gates on a video call, he recognizes Leonard from the previous night. Meanwhile, Amy is tired of Bernadette only talking about her children, so Bernadette uses her expanded parental brain to learn random science facts.
However, no legal action was required to end production of the other show: as soon as it became known that the show was unlicensed, the actors quit and the producers canceled it. Dmitriy Tankovich (who plays Leonard's counterpart, "Seva") said in an interview, "I'm upset. At first, the actors were told all legal issues were resolved. We didn't know it wasn't the case, so when the creators of The Big Bang Theory started talking about the show, I was embarrassed. I can't understand why our people first do, and then think. I consider this to be the rock bottom of my career. And I don't want to take part in a stolen show".