The episode opens with a short montage of clips from the series' twelve seasons, then segues to Sheldon and Amy, who are up late waiting for a call from the Nobel Committee. Following a prank call from Kripke, they are told they've won the Nobel Prize in Physics for their super-asymmetry work. The attention from the media and the university bothers Sheldon. Amy is saddened by an unflattering picture of her in a news report, so Raj convinces her to get a makeover. She loves her new look but Sheldon demands she change it back. Leonard calls him out for being rude, but Sheldon flees when he sees Penny emerge from the newly repaired elevator. Sheldon and Penny go to the Cheesecake Factory and Penny tells Sheldon that change is the only constant thing in life. On a TV, they see Bernadette and Howard take credit as Sheldon and Amy's best friends. Raj and Leonard defend Amy, with Leonard accidentally breaking Sheldon's DNA molecule model in Apartment 4A. Penny convinces Sheldon to ride in the elevator.

I am one of these people. And I have identified so much with Sheldon throughout the series, I do not struggle as hard as he did/do, but I have a good understanding of how it feels. And even worse, the realization of how it affects the ones closest to me. Ofc, I have come a far away with this. Intense therapy etc. But it is still there, like a haunting memory.
In March 2017, CBS renewed the series for two additional seasons, bringing its total to twelve, and running through the 2018–19 television season.[3] On August 22, 2018, CBS and Warner Bros. Television officially announced that the twelfth season would be the series' last. This stems from Jim Parsons' decision to leave the series at the end of the season if the show were to have been renewed for a thirteenth season.[1][4][5] The series concluded with an hour-long finale consisting of two back-to-back episodes on May 16, 2019.[6][7] A retrospective, hosted by Johnny Galecki and Kaley Cuoco, aired at 9:30 P.M. ET/PT, the night of the finale, following the season two finale of Young Sheldon.[8]
Sheldon and Amy struggle to choose a best man and maid of honor from their friends. They secretly decide to test and score them, allowing everyone to have an equal shot at either role. Once the gang finds out, none of them apart from Bernadette and Stuart want to be in the wedding. Sheldon settles for Stuart as best man but, once Leonard tells Sheldon that, as the groom, the decision is his alone, he picks Leonard. Amy is set to call Bernadette but, once Penny realizes Amy is her best friend, she immediately pitches herself for the position and Amy enthusiastically chooses her. Amy later makes Penny tell Bernadette the bad news.
According to Steve Holland who is the show-runner starting with this season, Wil Wheaton will return in this season since his absence from Season 10.[2] And this has confirmed to be true since it has been stated that he reappeared in "The Proton Regeneration" (S11E6), along with Professor Proton[3], their first appearances since "The Opening Night Excitation" (S9E11) and "The Celebration Experimentation", respectively and a span of 43 episodes and a span of 37 episodes, respectively. Wil also returned in the 15th episode. Wil will also return for Sheldon and Amy's Wedding.
After Sheldon has a food truck moved away from the building, Leonard and Penny are shocked to find he is the leader and sole member of the Tenants' Association for the building. Amy doesn't want to be caught in the middle but secretly suggests they rally support from the other tenants to vote Sheldon out. Nobody else supports Leonard so Amy tells them Sheldon was never added to the lease when he moved across the hall with her. Sheldon fires back with his own legal technicality so Amy is forced to support Leonard. She makes Sheldon happy by saying he can be Leonard's official opposition, making Leonard believe he made a mistake. Meanwhile, Howard and Raj find a drone. Raj returns it to the cute owner Cynthia and gets her number. Unfortunately, Cynthia watches footage of Raj on the drone and is immediately turned off.
^ From the eighth season onward, episodes of each season initially aired on Monday nights, before later returning to the Thursday night slot for the rest of the season. The eighth and ninth seasons returned on the seventh episode,[126][127] the tenth and eleventh seasons on the sixth episode,[128][129] and the twelfth season on the second episode.[130]
In scenes set at Howard's home, he interacts with his rarely-seen mother (voiced by Carol Ann Susi until her death) by shouting from room to room in the house. She similarly interacts with other characters in this manner.[85] She reflects the Jewish mother stereotype in some ways, such as being overly controlling of Howard's adult life and sometimes trying to make him feel guilty about causing her trouble. She is dependent on Howard, as she requires him to help her with her wig and makeup in the morning. Howard, in turn, is attached to his mother to the point where she still cuts his meat for him, takes him to the dentist, does his laundry and "grounds" him when he returns home after briefly moving out.[86] Until Howard's marriage to Bernadette in the fifth-season finale, Howard's former living situation led Leonard's psychiatrist mother to speculate that he may suffer from some type of pathology,[87] and Sheldon to refer to their relationship as Oedipal.[88] In season 8, Howard's mother dies in her sleep while in Florida, which devastates Howard and Stuart, who briefly lived with Mrs. Wolowitz.
When Leonard receives a braggy Christmas letter from his brother, he feels bad about how little he and Penny have achieved in the past year. Leonard wonders if he and Penny should be thinking about the next step after two years of marriage, like buying a house or having a baby. Penny tells him she wants to do all those things someday, but she has a bunch of stuff she would like to do first.
Wednesday night is the group's designated "comic book night"[77] because that is the day of the week when new comic books are released. The comic book store is run by fellow geek and recurring character Stuart. On a number of occasions, the group members have dressed up as pop culture characters, including The Flash, Aquaman, Frodo Baggins, Superman, Batman, Spock, The Doctor, Green Lantern, and Thor.[78] As a consequence of losing a bet to Stuart and Wil Wheaton, the group members are forced to visit the comic book store dressed as Catwoman, Wonder Woman, Batgirl, and Supergirl.[79] DC Comics announced that, to promote its comics, the company will sponsor Sheldon wearing Green Lantern T-shirts.[80]
Johnny Galecki as Leonard Hofstadter:[42] An experimental physicist with an IQ of 173, who received his PhD when he was 24 years old. Leonard is a nerd who loves video games, comic books, and Dungeons & Dragons. Leonard is the straight man of the series, in which he shares an apartment in Pasadena, CA, with Sheldon. Leonard is smitten with his new neighbor Penny when they first meet, and they eventually marry.
The fourth season's second half began on June 30, 2011. Season 5 began airing on November 3, 2011, at 8:00 p.m. as part of E4's Comedy Thursdays, acting as a lead-in to the channel's newest comedy, Perfect Couples. Episode 19, the highest-viewed episode of the season, attracted 1.4 million viewers.[145] Season 6 premiered on November 15, 2012, with 1.89 million viewers and a further 469,000 on the time shift channel, bringing the total to 2.31 million, E4's highest viewing ratings of 2012, and the highest the channel had received since June 2011. The sixth season returned in mid-2013 to finish airing the remaining episodes.[146] Season 7 premiered on E4 on October 31, 2013 at 8:30pm and hit multiple ratings records this season. The second half of season seven aired in mid 2014.[147] The eighth season premiered on E4 on October 23, 2014 at 8:30 p.m.[148] During its eighth season, The Big Bang Theory shared its 8:30 p.m. time period with fellow CBS comedy, 2 Broke Girls. Following the airing of the first eight episodes of that show's fourth season, The Big Bang Theory returned to finish airing its eighth season on March 19, 2015.[149]

Sara Gilbert as Leslie Winkle (recurring season 1, starring season 2, guest seasons 3, 9):[47][48][49] A physicist who works in the same lab as Leonard. In appearance, she is essentially Leonard's female counterpart and has conflicting scientific theories with Sheldon. Leslie has casual sex with Leonard and later Howard. Gilbert was promoted to a main cast member during the second season but resumed guest star status because producers could not come up with enough material for the character.[47] Gilbert returned to The Big Bang Theory for its 200th episode.[50]
Science has also interfered with the characters' romantic lives. Leslie breaks up with Leonard when he sides with Sheldon in his support for string theory rather than loop quantum gravity.[70] When Leonard joins Sheldon, Raj, and Howard on a three-month Arctic research trip, it separates Leonard and Penny at a time when their relationship is budding. When Bernadette takes an interest in Leonard's work, it makes both Penny and Howard envious and results in Howard confronting Leonard, and Penny asking Sheldon to teach her physics.[71] Sheldon and Amy also briefly end their relationship after an argument over which of their fields is superior.[72]
×