Wil Wheaton brings William Shatner on his Professor Proton show to meet Sheldon, who gets so excited that he vomits on Shatner. Going to Wil to apologize, he finds Wil hosts a Dungeons & Dragons group with his celebrity friends including Shatner. Finding out Stuart is in the group and never told them, the guys make Stuart panic and quit. Wil secretly invites Leonard who discovers that the group also includes Shatner, Kevin Smith, Joe Manganiello and Kareem Abdul-Jabbar. Leonard tells Penny, who tells Amy and Bernadette, all three women having a crush on Manganiello. Because of that indiscretion, Wil kicks out Leonard and admonishes the guys for using him for his connections, and says that one of the worst things about being a celebrity is not knowing whether someone will like him for himself. To apologize, the guys invite Wil to play D&D with them at Leonard’s apartment, but Wil, secretly in the middle of a game with Penny, Amy and Bernadette and the group, politely turns them down, before allowing the girls to send them a photo of the events as payback.
Penny and Bernadette attend a pharmaceuticals conference, where Bernadette's business rival Danny tries to recruit Penny. Bernadette is offended that Penny is considering the offer. At the meeting with Danny, Bernadette steps in to say Penny is the best saleswoman she knows and Penny agrees to keep working for Bernadette. Meanwhile, the rest of the gang does simple behavioral experiments on the Wolowitz children using a book Sheldon found. Leonard is shocked that his childhood was filled with these experiments; although his mother remembers that time with him fondly, she admits the experiment with him is not over. Raj figures Amy planted the book to get Sheldon to like babies, though Sheldon later states he would be open to having kids.

In scenes set at Howard's home, he interacts with his rarely-seen mother (voiced by Carol Ann Susi until her death) by shouting from room to room in the house. She similarly interacts with other characters in this manner.[85] She reflects the Jewish mother stereotype in some ways, such as being overly controlling of Howard's adult life and sometimes trying to make him feel guilty about causing her trouble. She is dependent on Howard, as she requires him to help her with her wig and makeup in the morning. Howard, in turn, is attached to his mother to the point where she still cuts his meat for him, takes him to the dentist, does his laundry and "grounds" him when he returns home after briefly moving out.[86] Until Howard's marriage to Bernadette in the fifth-season finale, Howard's former living situation led Leonard's psychiatrist mother to speculate that he may suffer from some type of pathology,[87] and Sheldon to refer to their relationship as Oedipal.[88] In season 8, Howard's mother dies in her sleep while in Florida, which devastates Howard and Stuart, who briefly lived with Mrs. Wolowitz.


When Mayim Bialik first learned she had to say goodbye to neurobiologist Amy Farrah Fowler, she opened up about the show ending in a blog post, asking, "And now I start to figure out what next. Where will life take me? Where will this career go? What do I want?" Up next she has a voice role in The Inspector Chronicles, a quasi-parody of Doctor Who making the leap from short to feature film. She'll reprise her role as the voice of the Inspector's time machine, known as B.O.O.T.H. Aside from that, she doesn't have any major projects lined up, aside from preparing to not see her close-knit cast the way she'd grown accustomed to. "We'll have to see what our lives look like," she told Us Weekly in early May about the chance they'll remain close. "I mean, we're all going to be on different schedules now; it's very different."
After Sheldon reminds the guys about the time they mined Bitcoin without him, the guys go on a quest to find their suddenly valuable missing cryptocurrency. They realize the currency is on a laptop which Leonard gave to Penny when they dating, which she then gave to her ex-boyfriend Zack. After Leonard and Penny go to Zack's apartment, he shows them a seven-year-old video that Penny recorded on the laptop soon after she broke up with Leonard. Leonard is touched by the video which shows a drunk Penny lamenting the break-up of her relationship with him.
When Raj misses out on a job at the planetarium, his father says he has no confidence because Howard always makes fun of him. Raj distances himself from Howard and later gets the job. Howard is hurt by this (even after apologizing to him) and tries to make amends with Raj after his first performance at the planetarium but, when he sees him get a date, he leaves without speaking to him, thinking that the latter's life is better without him. Meanwhile, Sheldon and Amy try randomly dividing up wedding tasks, but they keep arguing. The only thing they can agree on is to get married, so they decide to just get married at City Hall. However, Sheldon decides that he wants a first dance with his new wife and they go home to plan their wedding.
"Every heart expanding adventure begins with a single step. This was mine for @bigbangtheory_cbs," Rauch wrote. "My first episode. Or my first 'step-isode' - if you will. The second pic is shortly after I joined the cast (I couldn’t believe I had my very own dressing room)! The friendships and memories that would build from these moments simply overwhelm me."
Two months after the events of "The Change Constant", Sheldon and Leonard repair Sheldon's DNA molecule model as everyone prepares to fly to Sweden for the Nobel Prize award ceremony. Howard and Bernadette nervously leave their kids for the first time with Stuart and Denise, while Raj leaves his dog with Bert. Penny has become pregnant, though she and Leonard are keeping it a secret. On the flight, Raj thinks he spots Sarah Michelle Gellar. Penny's frequent bathroom trips make Sheldon fear she is sick. Leonard reveals the pregnancy to Sheldon, but instead of being excited for Penny, Sheldon is only selfishly relieved that he will not get sick and he exposes the pregnancy, offending Leonard. At the hotel, a series of minor incidents with their kids make Howard and Bernadette want to go home. Much to their dismay, Sheldon is still insensitive. Amy furiously tells Sheldon he broke their friends' hearts and they only tolerate him because he does not intentionally do so, which she also sometimes does. Everyone decides to stay for the ceremony and Raj brings Gellar. After they are awarded their medals, Amy encourages girls to pursue science while Sheldon thanks his family and then individually acknowledges each of his friends and Amy as his other family who always support him. The episode closes with the gang eating in Apartment 4A (an allusion to the final scene in the opening credits) as an acoustic version of the theme song's chorus plays.
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In May 2010, it was reported that the show had been picked up for syndication, mainly among Fox's owned and operated stations and other local stations, with Warner Bros. Television's sister cable network TBS holding the show's cable syndication rights. Broadcast of old shows began airing in September 2011. TBS now airs the series in primetime on Tuesdays, Wednesdays, and Thursdays, with evening broadcasts on Saturdays (TBS's former local sister station in Atlanta also holds local weeknight rights to the series).[157] Although details of the syndication deal have not been revealed, it was reported the deal "set a record price for a cable off-network sitcom purchase".[158] CTV holds national broadcast syndication rights in Canada, while sister cable network The Comedy Network holds cable rights.
In March 2017, CBS renewed the series for two additional seasons, bringing its total to twelve, and running through the 2018–19 television season.[3] On August 22, 2018, CBS and Warner Bros. Television officially announced that the twelfth season would be the series' last. This stems from Jim Parsons' decision to leave the series at the end of the season if the show were to have been renewed for a thirteenth season.[1][4][5] The series concluded with an hour-long finale consisting of two back-to-back episodes on May 16, 2019.[6][7] A retrospective, hosted by Johnny Galecki and Kaley Cuoco, aired at 9:30 P.M. ET/PT, the night of the finale, following the season two finale of Young Sheldon.[8]
When Mayim Bialik first learned she had to say goodbye to neurobiologist Amy Farrah Fowler, she opened up about the show ending in a blog post, asking, "And now I start to figure out what next. Where will life take me? Where will this career go? What do I want?" Up next she has a voice role in The Inspector Chronicles, a quasi-parody of Doctor Who making the leap from short to feature film. She'll reprise her role as the voice of the Inspector's time machine, known as B.O.O.T.H. Aside from that, she doesn't have any major projects lined up, aside from preparing to not see her close-knit cast the way she'd grown accustomed to. "We'll have to see what our lives look like," she told Us Weekly in early May about the chance they'll remain close. "I mean, we're all going to be on different schedules now; it's very different."
Melissa Rauch as Bernadette Rostenkowski-Wolowitz (recurring season 3, starring seasons 4–12):[51] A young woman who initially is a co-worker at The Cheesecake Factory with Penny to pay her way through graduate school, where she is studying microbiology. Bernadette is introduced to Howard by Penny; at first, they do not get along, apparently having nothing in common. They date and later get engaged and married. Although generally a sweet and good-natured person, Bernadette has a short fuse and can be vindictive and lash out when provoked.
Penny, who admits to missing Leonard in "The Roommate Transmogrification", accepts his request to renew their relationship in "The Beta Test Initiation". After Penny suggests having sex in "The Launch Acceleration", Leonard breaks the mood by proposing to her. Penny says "no" but does not break up with him. She stops a proposal a second time in "The Tangible Affection Proof". In the sixth-season episode, "The 43 Peculiarity", Penny finally tells Leonard that she loves him. Although they both feel jealousy when the other receives significant attention from the opposite sex, Penny is secure enough in their relationship to send him off on an exciting four-month expedition without worrying in "The Bon Voyage Reaction". After Leonard returns, their relationship blossoms over the seventh season. In the penultimate episode "The Gorilla Dissolution", Penny admits that they should marry and when Leonard realizes that she is serious, he proposes with a ring that he had been saving for years. Leonard and Penny decide to elope to Las Vegas in the season 8 finale, but beforehand, wanting no secrets, Leonard admits to kissing another woman, Mandy Chow (Melissa Tang) while on an expedition on the North Sea. Despite this, Leonard and Penny finally elope in the season 9 premiere.
Getting called into Human Resources for Amy's outburst, Mrs. Davis tells her and Sheldon they are blowing their chances at the Nobel Prize. Amy would be the fourth woman to win in Physics, pressuring her to be a role model for women everywhere. To calm down, they try a sensory deprivation tank, which Sheldon loves, but Amy's mood only worsens. Sheldon does not know how to help and ends up holding her while singing "Soft Kitty". A newly confident Amy goes back to Human Resources to be allowed to campaign again and shares a drink with Mrs. Davis. Meanwhile, Howard buys a scooter to ride with Raj like in the old days. Bernadette finds out and makes him sell it since it's too dangerous. Bert buys it and ends up meeting a nurse after he dislocates his arm in a wreck.
Cosmologist Stephen Hawking made a short guest appearance in the fifth-season episode;[57] in the eighth season, Hawking video conferences with Sheldon and Leonard, and makes another appearance in the 200th episode. In the fifth and sixth seasons, NASA astronaut Michael J. Massimino played himself multiple times in the role of Howard's fellow astronaut. Bill Nye appeared in the seventh and twelfth seasons.

With Leonard, Howard, Raj, and Amy accomplishing so much on their respective projects, Sheldon is forced to admit he has nothing important upon which to work. He makes Amy leave the apartment for a few days so he can focus, but cannot come up with any ideas and calls his mother as a distraction. Leonard and Amy have fun recreating experiments from when they were growing up, boring Penny, so she eats with Sheldon as he mulls over his scientific studies. Penny helps him realize that his study of dark matter is his rebound science from string theory, which Sheldon admits he never truly disregarded, but explaining string theory to her inspires Sheldon, helping him discover a potential breakthrough in the field. Meanwhile Howard is too busy with his family to be in the band with Raj, so Raj brings in Bert. But, when Howard annoys Bernadette by writing an astronaut-themed musical while she is on bed-rest, she makes him rejoin the band. The three are poorly received at a Bar mitzvah after singing Bert's original song about the boulder from Indiana Jones .

With Leonard, Howard, Raj, and Amy accomplishing so much on their respective projects, Sheldon is forced to admit he has nothing important upon which to work. He makes Amy leave the apartment for a few days so he can focus, but cannot come up with any ideas and calls his mother as a distraction. Leonard and Amy have fun recreating experiments from when they were growing up, boring Penny, so she eats with Sheldon as he mulls over his scientific studies. Penny helps him realize that his study of dark matter is his rebound science from string theory, which Sheldon admits he never truly disregarded, but explaining string theory to her inspires Sheldon, helping him discover a potential breakthrough in the field. Meanwhile Howard is too busy with his family to be in the band with Raj, so Raj brings in Bert. But, when Howard annoys Bernadette by writing an astronaut-themed musical while she is on bed-rest, she makes him rejoin the band. The three are poorly received at a Bar mitzvah after singing Bert's original song about the boulder from Indiana Jones .
Turning to total viewers, “Manifest” was the biggest gainer overall, on average adding 6.1 million viewers per episode. ABC’s “The Good Doctor” was second with an average viewer lift of just under 6 million. “New Amsterdam” (5.2 million viewer lift) and “A Million Little Things” (3.5 million viewer lift) were also among the top gainers in this measure, as was ABC’s “Whiskey Cavalier” (3.2 million viewer lift).
Howard dresses as Sheldon for Halloween at work, hurting Sheldon's feelings. When Howard does not apologize, Amy and Sheldon dress as Bernadette and Howard at Penny and Leonard's party, angering Bernadette. Sheldon and Bernadette later bond over their painful childhood memories. Leonard is upset that Penny does not seem to remember that their first kiss was on Halloween. Penny later admits she does remember, but does not like to think of their first kiss as an unromantic drunken hookup. She likes to imagine their first kiss was one they shared on Leonard's birthday, which pleases him.
In the apartment building where Sheldon, Leonard and Penny (and later Amy) live, the elevator has been out of order throughout most of the series, forcing characters to have to use the stairs. Stairway conversations between characters occur in almost every episode, often serving as a transition between longer scenes. The Season 3 episode, "The Staircase Implementation" reveals that the elevator was broken when Leonard was experimenting with rocket fuel.[89] In the penultimate episode of the series, the elevator is returned to an operational state, causing Sheldon some angst.
And while the actor, 44, doesn't have any other gigs lined up just yet—his most recent stab at producing, CBS' Living Biblically, was canceled after 13 episodes in 2018—he's busy preparing for his biggest role yet: fatherhood. On May 3, 2019, he and girlfriend Alaina Meyer announced that they were expecting their first child together. "We are absolutely over the moon to announce that we will soon be welcoming a little one into this crazy and wonderful world," he wrote on social media, sharing the big news. "There truly is love out there for all. We hope ours is the ember of yours, as we feel yours is the ember of ours."
Simon Helberg as Howard Wolowitz:[45] An aerospace engineer who got his Masters at MIT. Howard is Jewish and lived with his mother, Debbie (Carol Ann Susi). Unlike Sheldon, Leonard, Raj, Bernadette and Amy, Howard does not hold a doctorate. He goes into space, training as an astronaut and serving as a payload specialist. Howard initially fancies himself as a womanizer, but he later starts dating Bernadette, and they get engaged and married. Howard also has a tendency to waste money on toys and argues with Bernadette because of his oddly low income as an engineer and her high income as a pharmaceutical biochemist.
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