When Mayim Bialik first learned she had to say goodbye to neurobiologist Amy Farrah Fowler, she opened up about the show ending in a blog post, asking, "And now I start to figure out what next. Where will life take me? Where will this career go? What do I want?" Up next she has a voice role in The Inspector Chronicles, a quasi-parody of Doctor Who making the leap from short to feature film. She'll reprise her role as the voice of the Inspector's time machine, known as B.O.O.T.H. Aside from that, she doesn't have any major projects lined up, aside from preparing to not see her close-knit cast the way she'd grown accustomed to. "We'll have to see what our lives look like," she told Us Weekly in early May about the chance they'll remain close. "I mean, we're all going to be on different schedules now; it's very different."

Well done! Really great final episode writing. The characters we have enjoyed for 12 seasons went on with their lives. . .but reached a happy place at that moment of time. Amy and Sheldon recognized for their brilliance. Penny and Leonard growing into a family. Bernadette and Howard being concerned about the children. Raj having someone fun to attend the ceremony with. Way to tie things up on a pleasant note.
Been watching the show for 12 years and it’s had ups and downs.I liked how they settled on an emotional ending,rather than a clever , so called cutting edge one.The elevator finally working was a nice touch.Sheldon’s big speech highlighted how much the characters have grown emotionally over the years and how much respect the actors have for each other.The people on this show always seemed to be having a good time performing.That was a big part of the pleasure the audience took in watching it.The final 2 episodes honored the things fans loved about the show.
In March 2017, CBS renewed the series for two additional seasons, bringing its total to twelve, and running through the 2018–19 television season.[3] On August 22, 2018, CBS and Warner Bros. Television officially announced that the twelfth season would be the series' last. This stems from Jim Parsons' decision to leave the series at the end of the season if the show were to have been renewed for a thirteenth season.[1][4][5] The series concluded with an hour-long finale consisting of two back-to-back episodes on May 16, 2019.[6][7] A retrospective, hosted by Johnny Galecki and Kaley Cuoco, aired at 9:30 P.M. ET/PT, the night of the finale, following the season two finale of Young Sheldon.[8] 

Sheldon and Amy's wedding day arrives, with many friends and family attending, including Amy's domineering mother (Kathy Bates) and quiet father (Teller); Sheldon's mother Mary, brother George, and sister Missy, who is pregnant with her second child and separated from her husband; and Mark Hamill, who replaces Wil Wheaton as officiant as a favor to Howard who returned his lost dog. Sheldon cannot get his bow-tie to be symmetrical and conversations with Amy and his mother give him an epiphany about superasymmetry. Sheldon and Amy, along with Leonard, get caught up figuring out the math of the theory during the wedding ceremony, making Hamill take Star Wars questions to stall for time. Penny retrieves the couple, who then decide that they have the rest of their lives to make science together. Amy and Sheldon then express their vows. Amy recites a set of heartfelt vows, leaving Sheldon initially at a loss for words, before he reciprocates her loving words. They are pronounced as husband and wife.
Although earlier this season Penny (Kaley Cuocuo) told her husband Leonard (Johnny Galecki) that she never wanted kids, part two of the finale reveals that she is pregnant. But when Sheldon dismisses her announcement, Leonard angrily says “to hell with” his Nobel Prize. When his friends threaten to leave at his poor treatment of them, Sheldon takes time to self reflect.
When Leonard receives a braggy Christmas letter from his brother, he feels bad about how little he and Penny have achieved in the past year. Leonard wonders if he and Penny should be thinking about the next step after two years of marriage, like buying a house or having a baby. Penny tells him she wants to do all those things someday, but she has a bunch of stuff she would like to do first.
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