After the strike ended, the show was picked up for a second season, airing in the 2008–2009 season, premiering in the same time slot on September 22, 2008. With increasing ratings, the show received a two-year renewal through the 2010–11 season in 2009. In 2011, the show was picked up for three more seasons. In March 2014, the show was renewed again for three more years through the 2016–17 season. This marked the second time the series gained a three-year renewal. In March 2017, the series was renewed for two additional seasons, bringing its total to 12, and running through the 2018–19 television season.
The men are excited that Bill Gates is visiting Penny's pharmaceutical company, although she says that she cannot bring them along. Sheldon believes that it's an April Fools' Day prank. Leonard sees what hotel Gates is staying at on Penny's schedule, so he, Raj and Howard meet him in the lobby the day before. Once Sheldon sees proof, the men twice send him to the wrong hotel as real pranks. Penny says Leonard can meet Gates for real, so he fakes being sick to avoid him. When Penny puts Gates on a video call, he recognizes Leonard from the previous night. Meanwhile, Amy is tired of Bernadette only talking about her children, so Bernadette uses her expanded parental brain to learn random science facts.
Sheldon needs half a billion dollars to prove his latest concept of string theory, which the University cannot afford to fund. Crowdfunding and selling some of his most valuable comic books to Stuart give him a small start. When Raj mentions gambling in Las Vegas, Sheldon goes there but is caught calculating odds by security before he can make any bets. Meanwhile, Amy takes Penny and Bernadette shopping for her wedding dress. She loves an old-fashioned one that the other girls admit that they find ugly, though Penny assures Amy she can make her own decisions about her wedding. Sheldon, however, comes home and sees Amy in the dress and loves how she looks.