Sheldon's childhood friend from Texas, Tam, is visiting the university with his son. Sheldon does not want to see him and the others wonder why Sheldon has never mentioned Tam. Tam is unaware Sheldon is angry with him, thinking they just naturally drifted apart. Sheldon's brother George does not know the reason either. Sheldon eventually reveals Tam promised he would move to California with Sheldon, but then got a girlfriend and stayed with her, leaving Sheldon feeling abandoned. Tam and Sheldon make up and Sheldon has Leonard take Tam to the airport. Meanwhile, Penny and Bernadette want to get to know Anu, impressed by her connections in the hotel industry. They tell her embarrassing things about Raj and wonder if they can go out with her again after Raj confronts them.
With Leonard, Howard, Raj, and Amy accomplishing so much on their respective projects, Sheldon is forced to admit he has nothing important upon which to work. He makes Amy leave the apartment for a few days so he can focus, but cannot come up with any ideas and calls his mother as a distraction. Leonard and Amy have fun recreating experiments from when they were growing up, boring Penny, so she eats with Sheldon as he mulls over his scientific studies. Penny helps him realize that his study of dark matter is his rebound science from string theory, which Sheldon admits he never truly disregarded, but explaining string theory to her inspires Sheldon, helping him discover a potential breakthrough in the field. Meanwhile Howard is too busy with his family to be in the band with Raj, so Raj brings in Bert. But, when Howard annoys Bernadette by writing an astronaut-themed musical while she is on bed-rest, she makes him rejoin the band. The three are poorly received at a Bar mitzvah after singing Bert's original song about the boulder from Indiana Jones .
After Sheldon has a food truck moved away from the building, Leonard and Penny are shocked to find he is the leader and sole member of the Tenants' Association for the building. Amy doesn't want to be caught in the middle but secretly suggests they rally support from the other tenants to vote Sheldon out. Nobody else supports Leonard so Amy tells them Sheldon was never added to the lease when he moved across the hall with her. Sheldon fires back with his own legal technicality so Amy is forced to support Leonard. She makes Sheldon happy by saying he can be Leonard's official opposition, making Leonard believe he made a mistake. Meanwhile, Howard and Raj find a drone. Raj returns it to the cute owner Cynthia and gets her number. Unfortunately, Cynthia watches footage of Raj on the drone and is immediately turned off.
On March 13, 2017, CBS ordered the spin-off Young Sheldon series. Jon Favreau directed and executive produced the pilot. Created by Lorre and Molaro, the series follows 9-year-old Sheldon Cooper as he attends high school in East Texas. Alongside Armitage as 9-year-old Sheldon Cooper and Perry as Mary Cooper, Lance Barber stars as George Cooper, Sheldon's father; Raegan Revord stars as Missy Cooper, Sheldon's twin sister; and Montana Jordan as George Cooper Jr., Sheldon's older brother. Jim Parsons reprises his role as adult Sheldon Cooper, as narrator for the series. Parsons, Lorre, Molaro and Todd Spiewak will also serve as executive producers on the series, for Chuck Lorre Productions, Inc. in association with Warner Bros. Television. The show's pilot episode premiered on September 25, 2017. Subsequent weekly episodes began airing on November 2, 2017 following the broadcast of the 237th episode of The Big Bang Theory.
When Penny tells Leonard he needs to be more assertive in making decisions for himself, he starts standing up to Sheldon over small things. His confidence makes him want to demand the university support his idea for a plasma physics project. He threatens to quit if the university refuses, alarming both Sheldon and Penny, who consider this to be a risky career move. Sheldon is conflicted on whether or not he is being selfish over Leonard's decision, but Amy suggests that the fact that he is worried over Leonard's motivation proves that he does care about him, which he acknowledges. President Seibert refuses the project, but in order not to lose Leonard, gives him co-leadership over a photon entanglement project, leaving Leonard proud of himself and Penny impressed. Meanwhile, Raj shows Anu his lab, and suggests one possible answer for something he's seen in space might be alien life. When someone mentions this at his observatory presentation, the scientific community starts mocking him as a conspiracy theorist. Raj points out scientists should consider all possibilities when seeking the truth, though this causes people to think he believes in the Loch Ness Monster.
After Sheldon reminds the guys about the time they mined Bitcoin without him, the guys go on a quest to find their suddenly valuable missing cryptocurrency. They realize the currency is on a laptop which Leonard gave to Penny when they dating, which she then gave to her ex-boyfriend Zack. After Leonard and Penny go to Zack's apartment, he shows them a seven-year-old video that Penny recorded on the laptop soon after she broke up with Leonard. Leonard is touched by the video which shows a drunk Penny lamenting the break-up of her relationship with him.
When Leonard receives a braggy Christmas letter from his brother, he feels bad about how little he and Penny have achieved in the past year. Leonard wonders if he and Penny should be thinking about the next step after two years of marriage, like buying a house or having a baby. Penny tells him she wants to do all those things someday, but she has a bunch of stuff she would like to do first.