Leonard and Sheldon are brilliant physicists—geniuses in the laboratory but socially challenged everywhere else. Enter beautiful, street-smart neighbor Penny, who aims to teach them a thing or two about life. Despite their on-again, off-again relationship in the past, Leonard and Penny have finally gotten married. Even Sheldon has found a female companion, entering into a "relationship agreement" with neurobiologist Amy Farrah Fowler, and he recently took their relationship to the next level by marrying her after a long courtship. In their free time, Leonard and Sheldon enjoy fantasy role-playing games with their ever-expanding universe of friends, including fellow scientists Koothrappali, Wolowitz, and Wolowitz’s adorable microbiologist wife, Bernadette, who is adjusting to life with their two children.
Sheldon and Amy recruit Leonard to research and write citations for their paper on super asymmetry. While working in the campus library, Leonard and Raj discover a Russian paper that asserts that super asymmetry has no merit. Reluctantly, Leonard shares the news with Sheldon and Amy, who fall into a depressive state and do not leave their apartment. Meanwhile, Bernadette asks Denise to teach her how to play Fortnite: Battle Royale so that she can beat Howard. Despite losing to Howard in a rematch after all of her training, Bernadette revels in beating a disinterested Penny.

The Big Bang Theory signs off for good on Thursday, May 16, meaning that there's only one last bazinga left in the pipeline before we're forced to say farewell to Sheldon, Leonard, Penny, and the gang after 12 laugh-filled seasons. And while there's still a few questions left to be answered by the big one-hour series finale—Will the elevator ever be fixed? And will we ever learn Penny's maiden name?—there's a bigger one looming for when the credits roll and it's all over. 
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The sixth season boasts some of the highest-rated episodes for the show so far, with a then-new series high set with "The Bakersfield Expedition", with 20 million viewers,[97] a first for the series, which along with NCIS, made CBS the first network to have two scripted series reach that large an audience in the same week since 2007. In the sixth season, the show became the highest rated and viewed scripted show in the 18–49 demographic, trailing only the live regular NBC Sunday Night Football coverage,[98][99] and was third in total viewers, trailing NCIS and Sunday Night Football.[100] Season seven of the series opened strong, continuing the success gained in season six, with the second episode of the premiere, "The Deception Verification", setting the new series high in viewers with 20.44 million.[101][102]
And while the actor, 44, doesn't have any other gigs lined up just yet—his most recent stab at producing, CBS' Living Biblically, was canceled after 13 episodes in 2018—he's busy preparing for his biggest role yet: fatherhood. On May 3, 2019, he and girlfriend Alaina Meyer announced that they were expecting their first child together. "We are absolutely over the moon to announce that we will soon be welcoming a little one into this crazy and wonderful world," he wrote on social media, sharing the big news. "There truly is love out there for all. We hope ours is the ember of yours, as we feel yours is the ember of ours."
Two nerdy physicists share an apartment and an unlikely friendship with their beautiful neighbor with whom one of them is infatuated. Like the universe after the big bang, the show's popularity expanded, thanks to breakout star Jim Parsons, along with the chemistry among the friends and the developing romance between Leonard and Penny. The addition of Melissa Rauch and Mayim Bialik in later seasons also enhanced the stories and relationships of the leads.
Keith Carradine has appeared in three episode as Penny's father, Wyatt, first in Season 4. Katey Sagal, who played the on-screen mother of Kaley Cuoco's character in the 2002-2005 sitcom 8 Simple Rules, has appeared as Penny's mother in one episode of The Big Bang Theory. Jack McBrayer has appeared in one episode of The Big Bang Theory as Penny's brother, Randall.
The show originally centered on five characters living in Pasadena, California: Leonard Hofstadter and Sheldon Cooper, both physicists at Caltech, who share an apartment; Penny, a waitress and aspiring actress who lives across the hall; and Leonard and Sheldon's similarly geeky and socially awkward friends and co-workers, aerospace engineer Howard Wolowitz and astrophysicist Raj Koothrappali.[4][5] Over time, supporting characters were promoted to starring roles, including neuroscientist Amy Farrah Fowler, microbiologist Bernadette Rostenkowski, physicist Leslie Winkle and comic book store owner Stuart Bloom.
He's since become attached to a handful of Netflix projects, appearing in their recent Ted Bundy film Extremely Wicked, Shockingly Evil and Vile, executive producing mentee Ryan O'Connell's autobiographical comedy series Special, and signing on to reprise his role in their movie version of Ryan Murphy's Broadway production of The Boys in the Band, due on the streaming service in 2020.
In scenes set at Howard's home, he interacts with his rarely-seen mother (voiced by Carol Ann Susi until her death) by shouting from room to room in the house. She similarly interacts with other characters in this manner.[85] She reflects the Jewish mother stereotype in some ways, such as being overly controlling of Howard's adult life and sometimes trying to make him feel guilty about causing her trouble. She is dependent on Howard, as she requires him to help her with her wig and makeup in the morning. Howard, in turn, is attached to his mother to the point where she still cuts his meat for him, takes him to the dentist, does his laundry and "grounds" him when he returns home after briefly moving out.[86] Until Howard's marriage to Bernadette in the fifth-season finale, Howard's former living situation led Leonard's psychiatrist mother to speculate that he may suffer from some type of pathology,[87] and Sheldon to refer to their relationship as Oedipal.[88] In season 8, Howard's mother dies in her sleep while in Florida, which devastates Howard and Stuart, who briefly lived with Mrs. Wolowitz.
Kevin Sussman as Stuart Bloom (recurring seasons 2–5, 7, starring seasons 6, 8–12):[54] A mild-mannered, under-confident owner of a comic book store. A competent artist, Stuart is a graduate of the prestigious Rhode Island School of Design, and though he is socially awkward he possesses slightly better social skills. Stuart implies he is in financial trouble and that the comic book store now also is his home. He is later invited to join the guys' group while Howard is in space. Stuart gets a new job caring for Howard's mother later. After Mrs. Wolowitz's death, Stuart continues to live in her home, along with Howard and Bernadette, until he finds a place of his own.
Raj meets with the woman his father set up for him, Anu. Her commanding personality and practical approach to marriage startle Raj but he agrees to go ahead with it. Howard criticizes him but apologizes; he just never expected Raj to give up on romance. Raj admits this to Anu so she proposes to him, and he says yes. Raj also sends out a relationship questionnaire to Leonard and Penny, which soon reveals that Penny does not think she ever wants kids, upsetting Leonard, who would like to have kids someday, and their friends selfishly badger them on the issue. After telling her father Wyatt who is also upset, Leonard tells Penny that he'll be okay with it, as he never thought he'd have her in his life. To get his mind off of it, Penny rents Leonard a Batmobile to drive in and have fun with for the day. Meanwhile, Stuart starts bringing home Denise at night, which is very uncomfortable for Howard and Bernadette. When they also try to have time to themselves, they wake up their kids.

Howard dresses as Sheldon for Halloween at work, hurting Sheldon's feelings. When Howard does not apologize, Amy and Sheldon dress as Bernadette and Howard at Penny and Leonard's party, angering Bernadette. Sheldon and Bernadette later bond over their painful childhood memories. Leonard is upset that Penny does not seem to remember that their first kiss was on Halloween. Penny later admits she does remember, but does not like to think of their first kiss as an unromantic drunken hookup. She likes to imagine their first kiss was one they shared on Leonard's birthday, which pleases him.
The scene is all business – at least as much as you can expect from a bunch of cut-ups making a sitcom – and no one seems distracted by two significant events: The episode will mark the show’s 276th, moving it past “Cheers” to set a record for a sitcom filmed in front of a studio audience, and only three more remain to be shot for "Big Bang," co-created by Chuck Lorre and Bill Prady. 
Sheldon's childhood friend from Texas, Tam, is visiting the university with his son. Sheldon does not want to see him and the others wonder why Sheldon has never mentioned Tam. Tam is unaware Sheldon is angry with him, thinking they just naturally drifted apart. Sheldon's brother George does not know the reason either. Sheldon eventually reveals Tam promised he would move to California with Sheldon, but then got a girlfriend and stayed with her, leaving Sheldon feeling abandoned. Tam and Sheldon make up and Sheldon has Leonard take Tam to the airport. Meanwhile, Penny and Bernadette want to get to know Anu, impressed by her connections in the hotel industry. They tell her embarrassing things about Raj and wonder if they can go out with her again after Raj confronts them.
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