Two months after the events of "The Change Constant", Sheldon and Leonard repair Sheldon's DNA molecule model as everyone prepares to fly to Sweden for the Nobel Prize award ceremony. Howard and Bernadette nervously leave their kids for the first time with Stuart and Denise, while Raj leaves his dog with Bert. Penny has become pregnant, though she and Leonard are keeping it a secret. On the flight, Raj thinks he spots Sarah Michelle Gellar. Penny's frequent bathroom trips make Sheldon fear she is sick. Leonard reveals the pregnancy to Sheldon, but instead of being excited for Penny, Sheldon is only selfishly relieved that he will not get sick and he exposes the pregnancy, offending Leonard. At the hotel, a series of minor incidents with their kids make Howard and Bernadette want to go home. Much to their dismay, Sheldon is still insensitive. Amy furiously tells Sheldon he broke their friends' hearts and they only tolerate him because he does not intentionally do so, which she also sometimes does. Everyone decides to stay for the ceremony and Raj brings Gellar. After they are awarded their medals, Amy encourages girls to pursue science while Sheldon thanks his family and then individually acknowledges each of his friends and Amy as his other family who always support him. The episode closes with the gang eating in Apartment 4A (an allusion to the final scene in the opening credits) as an acoustic version of the theme song's chorus plays.
When Leonard receives a braggy Christmas letter from his brother, he feels bad about how little he and Penny have achieved in the past year. Leonard wonders if he and Penny should be thinking about the next step after two years of marriage, like buying a house or having a baby. Penny tells him she wants to do all those things someday, but she has a bunch of stuff she would like to do first.
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