Sheldon cannot find the perfect wedding date and begins talking in his sleep, adopting the persona of a laid-back person who goes with the flow. Amy and Penny believe that his subconscious mind is trying to tell him to be more relaxed; his attempt to be so while wearing flip-flops ends in disaster. He decides to leave all the wedding planning to Amy while he wears a Star Trek uniform underneath his tuxedo. Meanwhile, Raj and Stuart both become interested in Bernadette's new coworker Ruchi. While she likes them both as friends, she does not want a relationship with anyone.
Sheldon's mother Mary refuses to attend his wedding unless he invites his older brother George, with whom he is no longer speaking. Sheldon and Leonard fly to Texas to talk to George, who now owns a chain of tire stores. He refuses to attend and later explains to Leonard and Sheldon that the family sacrificed a lot to fund Sheldon's education, and he was stuck caring for their mother and sister Missy after their father died while Sheldon was in college. Sheldon never thanked him for this. Leonard takes George back to the hotel room where Sheldon apologizes for what he did and the brothers reconcile. George agrees to attend the wedding. Meanwhile, Howard and Bernadette's children contract pinkeye, infecting everyone except Penny, much to Amy's fury.

After learning Sheldon went behind their backs to work with the military again, Leonard and Howard say Sheldon is like Thomas Edison, taking credit for others' ideas, while they are more like Nikola Tesla. Leonard and Howard bring in Barry Kripke to help create a better idea than Sheldon's, but Kripke goes to the military himself, cutting all three of them out. Meanwhile, Bernadette fears Ruchi is trying to steal her projects at work while she is on maternity leave and enlists Raj to spy on her. Though he finds proof that Ruchi may be stealing from Bernadette, Raj tries to defend Ruchi like a boyfriend would, pointing out Bernadette's hypocrisy as she would most likely have stolen from other people's projects as well. Ruchi is not happy about this and promptly dumps Raj.

The Young and the Restless Spoilers: Nikki Can’t Stop Victor’s Custody Fight – Sharon’s Vengeful Fury Exposes Cover-Up Crew General Hospital Spoilers: Elizabeth Hendrickson Hints at Fan Favorite Destruction and Supercouple Breakup Shockers The Bold and the Beautiful Spoilers: Thorne and Katie Use Bill’s Secret Weapon Against Him – Shocking Scheme from New B&B Couple

One of the recurring plot lines is the relationship between Leonard and Penny. Leonard becomes attracted to Penny in the pilot episode and his need to do favors for her is a frequent point of humor in the first season. Meanwhile, Penny dates a series of muscular, attractive, unintelligent, and insensitive jocks. Their first long-term relationship begins when Leonard returns from a three-month expedition to the North Pole in the season 3 premiere. However, when Leonard tells Penny that he loves her, she realizes she cannot say it back. Both Leonard and Penny go on to date other people; most notably with Leonard dating Raj's sister Priya for much of season 4. This relationship is jeopardized when Leonard comes to falsely believe that Raj has slept with Penny, and ultimately ends when Priya sleeps with a former boyfriend in "The Good Guy Fluctuation".
While Jim Parsons was the one who'd had enough with The Big Bang Theory, opting not to renew his contract to play socially awkward theoretical physicist Sheldon Cooper and bringing about the demise of the show in the process, he won't be escaping the show's orbit entirely. He's still attached as both executive producer and narrator of prequel series Young Sheldon, returning for a third season on CBS this fall. "There was no factor; there was no situation that I was like, 'Well, I've had enough of that.' No. There was nothing like that. It was just…when you know, you know," he explained to The Hollywood Reporter in mid-May. 

After Sheldon reminds the guys about the time they mined Bitcoin without him, the guys go on a quest to find their suddenly valuable missing cryptocurrency. They realize the currency is on a laptop which Leonard gave to Penny when they dating, which she then gave to her ex-boyfriend Zack. After Leonard and Penny go to Zack's apartment, he shows them a seven-year-old video that Penny recorded on the laptop soon after she broke up with Leonard. Leonard is touched by the video which shows a drunk Penny lamenting the break-up of her relationship with him.
The Canadian alternative rock band Barenaked Ladies wrote and recorded the show's theme song, which describes the history and formation of the universe and the Earth. Co-lead singer Ed Robertson was asked by Lorre and Prady to write a theme song for the show after the producers attended one of the band's concerts in Los Angeles. By coincidence, Robertson had recently read Simon Singh's book Big Bang,[25][26] and at the concert improvised a freestyle rap about the origins of the universe.[citation needed] Lorre and Prady phoned him shortly thereafter and asked him to write the theme song. Having been asked to write songs for other films and shows, but ending up being rejected because producers favored songs by other artists, Robertson agreed to write the theme only after learning that Lorre and Prady had not asked anyone else.[citation needed]
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Amy and Howard begin collaborating on a neuroprosthetics project, upsetting Sheldon and Raj, who feel they are not spending as much time with them. When they seek solace with an annoyed Bernadette, she exploits the situation to trick Sheldon into doing Howard's chores. Penny successfully employs the approaches recommended in one of Bernadette's parenting books to deal with Sheldon, but Leonard believes she is coddling Sheldon too much. Sheldon and Raj resolve the issue of missing their significant others by spending time together.
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