"The Locomotive Manipulation" is the first episode in which Sheldon initiates a kiss with Amy. Although initially done in a fit of sarcasm, he discovers that he enjoys the feeling. Consequently, Sheldon slowly starts to open up over the rest of the season, and starts a more intimate relationship with Amy. However, in the season finale, Sheldon leaves temporarily to cope with several changes and Amy becomes distraught. However, in "The Prom Equivalency", he hides in his room to avoid going to a mock prom reenactment with her. In the resulting stand-off, Amy is about to confess that she loves Sheldon, but he surprises her by saying that he loves her too. This prompts Amy to have a panic attack.
Amy and Howard begin collaborating on a neuroprosthetics project, upsetting Sheldon and Raj, who feel they are not spending as much time with them. When they seek solace with an annoyed Bernadette, she exploits the situation to trick Sheldon into doing Howard's chores. Penny successfully employs the approaches recommended in one of Bernadette's parenting books to deal with Sheldon, but Leonard believes she is coddling Sheldon too much. Sheldon and Raj resolve the issue of missing their significant others by spending time together.
Producers, writers and others, including recurring guest star Wil Wheaton, joined the festivities on set and — hardly a spoiler alert — more laughing, crying and hugging ensued. Lorre embraced a happy Parsons, then moved on to each cast member as if it were a reception line. Galecki shared long, emotional hugs with his colleagues. After trying to keep their emotions under control for so long, it was finally time to just let go.
Regina King reprised her role as Janine Davis in “The Retraction Reaction”. Bob Newhart returned as Arthur Jeffries in “The Proton Regeneration”. Dean Norris reprised his role as Colonel Williams in “The Tesla Recoil”. Brian Thomas Smith returned as Zack in “The Bitcoin Entanglement”. Brian George guest starred as Raj’s father, Dr. Koothrappali, in “The Confidence Erosion”. Joshua Malina reprised his role as President Siebert in “The Monetary Insufficiency”.
Sheldon and Amy's paper is a huge success, but Sheldon is upset when he is not allowed to do interviews, while Amy gets all the attention. Denise asks Stuart to move in with her but he panics and flees. Raj sets up a doorbell camera app for Anu but sees her greet her ex-boyfriend. At a paintball match, all the feuding couples argue, with Raj saying he cannot trust Anu since he does not even know her, throwing the wedding into question. Stuart makes up with Denise by giving her a key to the Wolowitz house. Sheldon tries to do one interview with Amy but leaves when he is asked about the Russian scientists who had earlier disproved their theory.
However, no legal action was required to end production of the other show: as soon as it became known that the show was unlicensed, the actors quit and the producers canceled it. Dmitriy Tankovich (who plays Leonard's counterpart, "Seva") said in an interview, "I'm upset. At first, the actors were told all legal issues were resolved. We didn't know it wasn't the case, so when the creators of The Big Bang Theory started talking about the show, I was embarrassed. I can't understand why our people first do, and then think. I consider this to be the rock bottom of my career. And I don't want to take part in a stolen show".