After Sheldon has a food truck moved away from the building, Leonard and Penny are shocked to find he is the leader and sole member of the Tenants' Association for the building. Amy doesn't want to be caught in the middle but secretly suggests they rally support from the other tenants to vote Sheldon out. Nobody else supports Leonard so Amy tells them Sheldon was never added to the lease when he moved across the hall with her. Sheldon fires back with his own legal technicality so Amy is forced to support Leonard. She makes Sheldon happy by saying he can be Leonard's official opposition, making Leonard believe he made a mistake. Meanwhile, Howard and Raj find a drone. Raj returns it to the cute owner Cynthia and gets her number. Unfortunately, Cynthia watches footage of Raj on the drone and is immediately turned off.
Professor Proton, Sheldon's favorite childhood show, is being rebooted. After unsuccessfully auditioning for the part, he goes to Wil Wheaton for acting tips for his second audition. However, Sheldon is later dismayed when Wil is offered the role instead. Talking it over with Arthur in his dreams, he is still upset to see his idol replaced and considers Wil an enemy again. Meanwhile, Howard gets a vasectomy while Bernadette is on bed rest. Penny offers to take care of Halley for them, but they insult her by expecting her to be irresponsible. Halley ends up saying her first word by calling Penny "Mama."
Wil Wheaton brings William Shatner on his Professor Proton show to meet Sheldon, who gets so excited that he vomits on Shatner. Going to Wil to apologize, he finds Wil hosts a Dungeons & Dragons group with his celebrity friends including Shatner. Finding out Stuart is in the group and never told them, the guys make Stuart panic and quit. Wil secretly invites Leonard who discovers that the group also includes Shatner, Kevin Smith, Joe Manganiello and Kareem Abdul-Jabbar. Leonard tells Penny, who tells Amy and Bernadette, all three women having a crush on Manganiello. Because of that indiscretion, Wil kicks out Leonard and admonishes the guys for using him for his connections, and says that one of the worst things about being a celebrity is not knowing whether someone will like him for himself. To apologize, the guys invite Wil to play D&D with them at Leonard’s apartment, but Wil, secretly in the middle of a game with Penny, Amy and Bernadette and the group, politely turns them down, before allowing the girls to send them a photo of the events as payback.
Warner Bros. Television controls the online rights for the show. Full episodes are available at tv.com, while short clips and recently aired full episodes are available on cbs.com. In Canada, recent episode(s) and pictures are available on CTV.ca. Additionally in Canada, the first six seasons are available for streaming on Bell Media's CraveTV. After the show has aired in New Zealand the shows are available in full online at TVNZ's on demand web service.
Melissa Rauch as Bernadette Rostenkowski-Wolowitz (recurring season 3, starring seasons 4–12): A young woman who initially is a co-worker at The Cheesecake Factory with Penny to pay her way through graduate school, where she is studying microbiology. Bernadette is introduced to Howard by Penny; at first, they do not get along, apparently having nothing in common. They date and later get engaged and married. Although generally a sweet and good-natured person, Bernadette has a short fuse and can be vindictive and lash out when provoked.
As the theme of the show revolves around science, many distinguished and high-profile scientists have appeared as guest stars on the show. Famous astrophysicist and Nobel laureate George Smoot had a cameo appearance in the second season. Theoretical physicist Brian Greene appeared in the fourth season, as well as astrophysicist, science populizer, and physics outreach specialist Neil deGrasse Tyson, who also appeared in the twelfth season.
Regina King reprised her role as Janine Davis in “The Retraction Reaction”. Bob Newhart returned as Arthur Jeffries in “The Proton Regeneration”. Dean Norris reprised his role as Colonel Williams in “The Tesla Recoil”. Brian Thomas Smith returned as Zack in “The Bitcoin Entanglement”. Brian George guest starred as Raj’s father, Dr. Koothrappali, in “The Confidence Erosion”. Joshua Malina reprised his role as President Siebert in “The Monetary Insufficiency”.
Sheldon needs half a billion dollars to prove his latest concept of string theory, which the University cannot afford to fund. Crowdfunding and selling some of his most valuable comic books to Stuart give him a small start. When Raj mentions gambling in Las Vegas, Sheldon goes there but is caught calculating odds by security before he can make any bets. Meanwhile, Amy takes Penny and Bernadette shopping for her wedding dress. She loves an old-fashioned one that the other girls admit that they find ugly, though Penny assures Amy she can make her own decisions about her wedding. Sheldon, however, comes home and sees Amy in the dress and loves how she looks.