In scenes set at Howard's home, he interacts with his rarely-seen mother (voiced by Carol Ann Susi until her death) by shouting from room to room in the house. She similarly interacts with other characters in this manner. She reflects the Jewish mother stereotype in some ways, such as being overly controlling of Howard's adult life and sometimes trying to make him feel guilty about causing her trouble. She is dependent on Howard, as she requires him to help her with her wig and makeup in the morning. Howard, in turn, is attached to his mother to the point where she still cuts his meat for him, takes him to the dentist, does his laundry and "grounds" him when he returns home after briefly moving out. Until Howard's marriage to Bernadette in the fifth-season finale, Howard's former living situation led Leonard's psychiatrist mother to speculate that he may suffer from some type of pathology, and Sheldon to refer to their relationship as Oedipal. In season 8, Howard's mother dies in her sleep while in Florida, which devastates Howard and Stuart, who briefly lived with Mrs. Wolowitz.
While Jim Parsons was the one who'd had enough with The Big Bang Theory, opting not to renew his contract to play socially awkward theoretical physicist Sheldon Cooper and bringing about the demise of the show in the process, he won't be escaping the show's orbit entirely. He's still attached as both executive producer and narrator of prequel series Young Sheldon, returning for a third season on CBS this fall. "There was no factor; there was no situation that I was like, 'Well, I've had enough of that.' No. There was nothing like that. It was just…when you know, you know," he explained to The Hollywood Reporter in mid-May.
Sheldon and Amy are surprised to find that Wil Wheaton's new Professor Proton show is actually very entertaining and that Wil had Howard on as a guest. On Howard's suggestion, Sheldon apologizes to Wil, mending their friendship, and tells him he wants to be on the show; but Wil asks for Amy. Sheldon tells her to do it, but she says she often doesn't do things to avoid upsetting him. Sheldon is horrified when he realises how selfish he has been, especially when he finds out that the men do the same for him. Sheldon encourages Amy to go on the show to inspire girls to pursue science while trying to control his obvious jealousy for her. Meanwhile, Leonard writes a book about a physicist that solves a murder, the protagonist Logan Dean is based on himself. Bernadette points out Logan's mean boss Illsa is similar to Penny, who thinks it is based on Bernadette, though Leonard does not correct her. However, Bernadette tells Penny the truth, upsetting her and making her mad at Leonard. After calling his mother for advice, Leonard learns that Illsa is actually like her; but abandons the book when he realizes he wrote romantic tension into the relationship between the characters.