Simon Helberg as Howard Wolowitz:[45] An aerospace engineer who got his Masters at MIT. Howard is Jewish and lived with his mother, Debbie (Carol Ann Susi). Unlike Sheldon, Leonard, Raj, Bernadette and Amy, Howard does not hold a doctorate. He goes into space, training as an astronaut and serving as a payload specialist. Howard initially fancies himself as a womanizer, but he later starts dating Bernadette, and they get engaged and married. Howard also has a tendency to waste money on toys and argues with Bernadette because of his oddly low income as an engineer and her high income as a pharmaceutical biochemist.
Johnny Galecki as Leonard Hofstadter:[42] An experimental physicist with an IQ of 173, who received his PhD when he was 24 years old. Leonard is a nerd who loves video games, comic books, and Dungeons & Dragons. Leonard is the straight man of the series, in which he shares an apartment in Pasadena, CA, with Sheldon. Leonard is smitten with his new neighbor Penny when they first meet, and they eventually marry.
Turning to total viewers, “Manifest” was the biggest gainer overall, on average adding 6.1 million viewers per episode. ABC’s “The Good Doctor” was second with an average viewer lift of just under 6 million. “New Amsterdam” (5.2 million viewer lift) and “A Million Little Things” (3.5 million viewer lift) were also among the top gainers in this measure, as was ABC’s “Whiskey Cavalier” (3.2 million viewer lift).
"It's different for everybody. It was time for me and I felt that. It's both simple and complicated. I don't have a diary that I could bring out and say, 'Here are the reasons as far as quote-unquote future plans in a concrete way or (that I had) a problem with coming here.' None of those things were true," he says. "I felt it was the right moment for me. But, it only helps so much to go through the end of something like this feeling you've made the right choice. It's still exceedingly emotional." 
Penny, who admits to missing Leonard in "The Roommate Transmogrification", accepts his request to renew their relationship in "The Beta Test Initiation". After Penny suggests having sex in "The Launch Acceleration", Leonard breaks the mood by proposing to her. Penny says "no" but does not break up with him. She stops a proposal a second time in "The Tangible Affection Proof". In the sixth-season episode, "The 43 Peculiarity", Penny finally tells Leonard that she loves him. Although they both feel jealousy when the other receives significant attention from the opposite sex, Penny is secure enough in their relationship to send him off on an exciting four-month expedition without worrying in "The Bon Voyage Reaction". After Leonard returns, their relationship blossoms over the seventh season. In the penultimate episode "The Gorilla Dissolution", Penny admits that they should marry and when Leonard realizes that she is serious, he proposes with a ring that he had been saving for years. Leonard and Penny decide to elope to Las Vegas in the season 8 finale, but beforehand, wanting no secrets, Leonard admits to kissing another woman, Mandy Chow (Melissa Tang) while on an expedition on the North Sea. Despite this, Leonard and Penny finally elope in the season 9 premiere.

Regina King reprised her role as Janine Davis in “The Retraction Reaction”. Bob Newhart returned as Arthur Jeffries in “The Proton Regeneration”. Dean Norris reprised his role as Colonel Williams in “The Tesla Recoil”. Brian Thomas Smith returned as Zack in “The Bitcoin Entanglement”. Brian George guest starred as Raj’s father, Dr. Koothrappali, in “The Confidence Erosion”. Joshua Malina reprised his role as President Siebert in “The Monetary Insufficiency”.


Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend. Written by Huggo
I have watched this program since the beginning. It has very often been zany and unpredictable….tonight it was neither. So everything is “nicey nicey” on the last show, but far from comedy. There have been many memorable comedy series finales …Newhart, Seinfeld, etc……unfortunaely, thus was not one of those and I am sad that a potentially great TV moment was squandered
The sixth season boasts some of the highest-rated episodes for the show so far, with a then-new series high set with "The Bakersfield Expedition", with 20 million viewers,[97] a first for the series, which along with NCIS, made CBS the first network to have two scripted series reach that large an audience in the same week since 2007. In the sixth season, the show became the highest rated and viewed scripted show in the 18–49 demographic, trailing only the live regular NBC Sunday Night Football coverage,[98][99] and was third in total viewers, trailing NCIS and Sunday Night Football.[100] Season seven of the series opened strong, continuing the success gained in season six, with the second episode of the premiere, "The Deception Verification", setting the new series high in viewers with 20.44 million.[101][102]
The show made its United Kingdom debut on Channel 4 on February 14, 2008. The show was also shown as a 'first-look' on Channel 4's digital offshoot E4 prior to the main channel's airing. While the show's ratings were not deemed strong enough for the main channel, they were considered the opposite for E4. For each following season, all episodes were shown first-run on E4, with episodes only aired on the main channel in a repeat capacity, usually on a weekend morning. From the third season, the show aired in two parts, being split so that it could air new episodes for longer throughout the year. This was due to rising ratings. The first part began airing on December 17, 2009, at 9:00 p.m. while the second part, containing the remaining eleven episodes, began airing in the same time period from May 6, 2010. The first half of the fourth season began airing on November 4, 2010, at 9:00 p.m., drawing 877,000 viewers, with a further 256,000 watching on the E4+1 hour service. This gave the show an overall total of 1.13 million viewers, making it E4's most-watched programme for that week. The increased ratings continued over subsequent weeks.[144]
Sheldon needs half a billion dollars to prove his latest concept of string theory, which the University cannot afford to fund. Crowdfunding and selling some of his most valuable comic books to Stuart give him a small start. When Raj mentions gambling in Las Vegas, Sheldon goes there but is caught calculating odds by security before he can make any bets. Meanwhile, Amy takes Penny and Bernadette shopping for her wedding dress. She loves an old-fashioned one that the other girls admit that they find ugly, though Penny assures Amy she can make her own decisions about her wedding. Sheldon, however, comes home and sees Amy in the dress and loves how she looks.
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Well done! Really great final episode writing. The characters we have enjoyed for 12 seasons went on with their lives. . .but reached a happy place at that moment of time. Amy and Sheldon recognized for their brilliance. Penny and Leonard growing into a family. Bernadette and Howard being concerned about the children. Raj having someone fun to attend the ceremony with. Way to tie things up on a pleasant note.
When Mayim Bialik first learned she had to say goodbye to neurobiologist Amy Farrah Fowler, she opened up about the show ending in a blog post, asking, "And now I start to figure out what next. Where will life take me? Where will this career go? What do I want?" Up next she has a voice role in The Inspector Chronicles, a quasi-parody of Doctor Who making the leap from short to feature film. She'll reprise her role as the voice of the Inspector's time machine, known as B.O.O.T.H. Aside from that, she doesn't have any major projects lined up, aside from preparing to not see her close-knit cast the way she'd grown accustomed to. "We'll have to see what our lives look like," she told Us Weekly in early May about the chance they'll remain close. "I mean, we're all going to be on different schedules now; it's very different."
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