Leonard's mother Beverly visits, and he is thrilled when she takes an interest in his work. However, when he learns that she is doing research on him for a new parenting book, he is furious. He prepares to tell her how she let him down over the years, but instead chooses to accept and forgive her, and forgive himself for holding onto that resentment for so long. Beverley is touched that he forgave her and they share a genuine hug. Meanwhile, Anu gets a job offer in London. Raj prepares to fly out and propose to her, ready to follow her if she accepts. Howard stops Raj at the airport, saying there is a better match out there for him, convincing Raj to return home. Stuart and Denise are bothered by her creepy roommate Mitch, while Bernadette and Howard are tired of Denise constantly staying overnight with Stuart at their house. Stuart says he is ready to move in with Denise, and they say they love each other while convincing Mitch to move out.
“The Big Bang Theory” premiered on Sept. 24, 2007, and for most of its run, was primetime’s most-watched comedy series. It remains one of the most successful sitcoms in TV history — and the longest-running multi-cam comedy of all time (recently surpassing “Cheers”). It has generated an estimated $1 billion and counting in syndication. The show has received 52 Emmy Award nominations and 10 wins, seven Golden Globe nominations, and the spinoff prequel, “Young Sheldon.”
The episode opens with a short montage of clips from the series' twelve seasons, then segues to Sheldon and Amy, who are up late waiting for a call from the Nobel Committee. Following a prank call from Kripke, they are told they've won the Nobel Prize in Physics for their super-asymmetry work. The attention from the media and the university bothers Sheldon. Amy is saddened by an unflattering picture of her in a news report, so Raj convinces her to get a makeover. She loves her new look but Sheldon demands she change it back. Leonard calls him out for being rude, but Sheldon flees when he sees Penny emerge from the newly repaired elevator. Sheldon and Penny go to the Cheesecake Factory and Penny tells Sheldon that change is the only constant thing in life. On a TV, they see Bernadette and Howard take credit as Sheldon and Amy's best friends. Raj and Leonard defend Amy, with Leonard accidentally breaking Sheldon's DNA molecule model in Apartment 4A. Penny convinces Sheldon to ride in the elevator.
I am one of these people. And I have identified so much with Sheldon throughout the series, I do not struggle as hard as he did/do, but I have a good understanding of how it feels. And even worse, the realization of how it affects the ones closest to me. Ofc, I have come a far away with this. Intense therapy etc. But it is still there, like a haunting memory. 
Leonard tells Zack and Marissa he will father their child, but Penny tries to seduce him despite knowing he has to be abstinent for a few days. Her visiting father, Wyatt, points out her actions suggest she is more conflicted over having kids than she lets on, which she admits. Wyatt says he will support her no matter what. Meanwhile, Sheldon and Amy warn that he will not be allowed to raise a child that is not his. Leonard decides not to go through with it; he tells Zack to have Sheldon be the donor, but Amy forbids it. Meanwhile, Howard turns Raj's cancelled bachelor party into a couples' trip into a zero-gravity aircraft, though he's convinced that Bernadette would hate it. Bernadette tries to get out of it so Howard sits out, forcing Bernadette to go through with it just to prove him wrong, though she does not enjoy it.

Sheldon and Amy are surprised to find that Wil Wheaton's new Professor Proton show is actually very entertaining and that Wil had Howard on as a guest. On Howard's suggestion, Sheldon apologizes to Wil, mending their friendship, and tells him he wants to be on the show; but Wil asks for Amy. Sheldon tells her to do it, but she says she often doesn't do things to avoid upsetting him. Sheldon is horrified when he realises how selfish he has been, especially when he finds out that the men do the same for him. Sheldon encourages Amy to go on the show to inspire girls to pursue science while trying to control his obvious jealousy for her. Meanwhile, Leonard writes a book about a physicist that solves a murder, the protagonist Logan Dean is based on himself. Bernadette points out Logan's mean boss Illsa is similar to Penny, who thinks it is based on Bernadette, though Leonard does not correct her. However, Bernadette tells Penny the truth, upsetting her and making her mad at Leonard. After calling his mother for advice, Leonard learns that Illsa is actually like her; but abandons the book when he realizes he wrote romantic tension into the relationship between the characters.
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