Sheldon is annoyed that Amy does not have time to work on the super-asymmetry project with him so he talks President Siebert into getting her removed from her own project at the university. Amy is angry at both of them as she wants to still have her own identity outside the marriage. When confronted by Amy, Siebert apologizes to her but states that it will be difficult for the university to give her her project back. After talking with Arthur Jeffries in a dream, Sheldon apologizes to Amy and both of them talk about their fears in their marriage. Meanwhile, Raj does not want to have Howard join him in his show at the planetarium, thinking he'd just use his astronaut status to make it about himself. Raj eventually lets him join in and Raj and Howard spend the whole time complimenting each other, surprising Bernadette, Leonard and Penny.
Turning to total viewers, “Manifest” was the biggest gainer overall, on average adding 6.1 million viewers per episode. ABC’s “The Good Doctor” was second with an average viewer lift of just under 6 million. “New Amsterdam” (5.2 million viewer lift) and “A Million Little Things” (3.5 million viewer lift) were also among the top gainers in this measure, as was ABC’s “Whiskey Cavalier” (3.2 million viewer lift).
The Big Bang Theory started off quietly in Canada, but managed to garner major success in later seasons. The Big Bang Theory is telecast throughout Canada via the CTV Television Network in simultaneous substitution with cross-border CBS affiliates. Now immensely popular in Canada, The Big Bang Theory is also rerun daily on the Canadian cable channel The Comedy Network.
The men are excited that Bill Gates is visiting Penny's pharmaceutical company, although she says that she cannot bring them along. Sheldon believes that it's an April Fools' Day prank. Leonard sees what hotel Gates is staying at on Penny's schedule, so he, Raj and Howard meet him in the lobby the day before. Once Sheldon sees proof, the men twice send him to the wrong hotel as real pranks. Penny says Leonard can meet Gates for real, so he fakes being sick to avoid him. When Penny puts Gates on a video call, he recognizes Leonard from the previous night. Meanwhile, Amy is tired of Bernadette only talking about her children, so Bernadette uses her expanded parental brain to learn random science facts.
Sheldon's childhood friend from Texas, Tam, is visiting the university with his son. Sheldon does not want to see him and the others wonder why Sheldon has never mentioned Tam. Tam is unaware Sheldon is angry with him, thinking they just naturally drifted apart. Sheldon's brother George does not know the reason either. Sheldon eventually reveals Tam promised he would move to California with Sheldon, but then got a girlfriend and stayed with her, leaving Sheldon feeling abandoned. Tam and Sheldon make up and Sheldon has Leonard take Tam to the airport. Meanwhile, Penny and Bernadette want to get to know Anu, impressed by her connections in the hotel industry. They tell her embarrassing things about Raj and wonder if they can go out with her again after Raj confronts them.
When Leonard receives a braggy Christmas letter from his brother, he feels bad about how little he and Penny have achieved in the past year. Leonard wonders if he and Penny should be thinking about the next step after two years of marriage, like buying a house or having a baby. Penny tells him she wants to do all those things someday, but she has a bunch of stuff she would like to do first.